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    Mybph myosin binding protein H [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83708, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Mybphprovided by RGD
    Official Full Name
    myosin binding protein Hprovided by RGD
    Primary source
    RGD:620287
    See related
    EnsemblRapid:ENSRNOG00000003336 AllianceGenome:RGD:620287
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in sarcomere organization. Predicted to be located in intracellular membraneless organelle and myosin filament. Predicted to be active in M band. Used to study hypertension. Orthologous to human MYBPH (myosin binding protein H). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 536.7), Brain (RPKM 92.3) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mybph in Genome Data Viewer
    Location:
    13q13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (48205162..48212928)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (45653156..45660893)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (51034228..51041903)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552406 Neighboring gene chitinase 3 like 1 Neighboring gene adenosine A1 receptor Neighboring gene uncharacterized LOC120096189 Neighboring gene myogenin Neighboring gene PTPRF interacting protein alpha 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MYBPH inhibits vascular smooth muscle cell migration and attenuates neointimal hyperplasia in a rat carotid balloon-injury model. Zhu T, et al. Exp Cell Res, 2017 Oct 1. PMID 28800959
    2. Ascribing novel functions to the sarcomeric protein, myosin binding protein H (MyBPH) in cardiac sarcomere contraction. Mouton J, et al. Exp Cell Res, 2015 Feb 15. PMID 25449695
    3. Nucleotide and deduced amino acid sequences of rat myosin binding protein H (MyBP-H). Jung J, et al. Arch Pharm Res, 1998 Dec. PMID 9868543
    4. Congenic mapping and sequence analysis of the Renin locus. Flister MJ, et al. Hypertension, 2013 Apr. PMID 23460292, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PDGF-induced VSMC migration was inhibited by adenovirus-mediated expression of MYBPH whereas it was enhanced by small interfering RNA knockdown of MYBPH.
      Title: MYBPH inhibits vascular smooth muscle cell migration and attenuates neointimal hyperplasia in a rat carotid balloon-injury model.
    2. This study provides evidence for a potential role of MyBPH in hypertrophic cardiomyopathy.
      Title: Ascribing novel functions to the sarcomeric protein, myosin binding protein H (MyBPH) in cardiac sarcomere contraction.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in M band IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membraneless organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in myosin filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin-binding protein H
    Names
    H-protein
    myBP-H
    norvegicus myosin binding protein H

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031813.2 → NP_114001.2  myosin-binding protein H

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6ICA9, G3V6F1, Q6P6V8
      Related
      ENSRNOP00000004528.4, ENSRNOT00000004528.8
      Conserved Domains (5) summary
      PRK12270
      Location:5 → 83
      kgd; multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
      cd00063
      Location:78 → 164
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:389 → 478
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:392 → 395
      Ig; Ig strand A [structural motif]
      cd05748
      Location:190 → 270
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      48205162..48212928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249888.5 → XP_006249950.1  myosin-binding protein H isoform X1

      UniProtKB/TrEMBL
      Q6P6V8
      Related
      ENSRNOP00000111832.1, ENSRNOT00000151198.1
      Conserved Domains (5) summary
      cd00096
      Location:408 → 472
      Ig; Immunoglobulin domain
      cd05748
      Location:198 → 270
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      smart00410
      Location:189 → 270
      IG_like; Immunoglobulin like
      cd00063
      Location:78 → 164
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:389 → 478
      I-set; Immunoglobulin I-set domain

    2. XM_006249889.5 → XP_006249951.1  myosin-binding protein H isoform X2

      See identical proteins and their annotated locations for XP_006249951.1

      UniProtKB/TrEMBL
      A6ICA9, G3V6F1, Q6P6V8
      Conserved Domains (5) summary
      PRK12270
      Location:5 → 83
      kgd; multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
      cd00063
      Location:78 → 164
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:389 → 478
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:392 → 395
      Ig; Ig strand A [structural motif]
      cd05748
      Location:190 → 270
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

    RNA

    1. XR_358910.5 RNA Sequence

    2. XR_358909.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88599.1 GenPept UniProtKB/Swiss-Prot:O88599

    Gene LinkOut

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