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    Ubr1 ubiquitin protein ligase E3 component n-recognin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499877, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ubr1provided by RGD
    Official Full Name
    ubiquitin protein ligase E3 component n-recognin 1provided by RGD
    Primary source
    RGD:1562326
    See related
    EnsemblRapid:ENSRNOG00000037207 AllianceGenome:RGD:1562326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562326
    Summary
    Predicted to enable L-leucine binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular response to L-leucine; negative regulation of TOR signaling; and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome complex and ubiquitin ligase complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Johanson-Blizzard syndrome and cardiovascular system disease. Orthologous to human UBR1 (ubiquitin protein ligase E3 component n-recognin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 194.3), Lung (RPKM 179.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ubr1 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (128265160..128377830, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (107813721..107921701, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (112800557..112910038, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene StAR-related lipid transfer domain containing 9 Neighboring gene uncharacterized LOC120101914 Neighboring gene codanin 1 Neighboring gene tau tubulin kinase 2 Neighboring gene uncharacterized LOC134486141 Neighboring gene transmembrane protein 62 Neighboring gene cyclin D1 binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Upregulation of UBR1 m6A Methylation by METTL14 Inhibits Autophagy in Spinal Cord Injury. Wang C, et al. eNeuro, 2023 Jun. PMID 37094938, Free PMC Article
    2. Recurrent Johanson-Blizzard syndrome in a triplet pregnancy complicated by urethral obstruction sequence: a clinical, molecular, and immunohistochemical approach. Schoner K, et al. Pediatr Dev Pathol, 2012 Jan-Feb. PMID 21711208
    3. Johanson-Blizzard syndrome caused by identical UBR1 mutations in two unrelated girls, one with a cardiomyopathy. Elting M, et al. Am J Med Genet A, 2008 Dec 1. PMID 19006206
    4. Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway. Kume K, et al. Genes Cells, 2010 Apr 1. PMID 20298436
    5. Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway. Kwon YT, et al. Mol Cell Biol, 2001 Dec. PMID 11689692, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulation of UBR1 m6A Methylation by METTL14 Inhibits Autophagy in Spinal Cord Injury.
      Title: Upregulation of UBR1 m6A Methylation by METTL14 Inhibits Autophagy in Spinal Cord Injury.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-leucine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to L-leucine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase UBR1
    NP_001171543.1
    XP_063140437.1
    XP_063140438.1
    XP_063140439.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001178072.2 → NP_001171543.1  E3 ubiquitin-protein ligase UBR1

      See identical proteins and their annotated locations for NP_001171543.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZZN6, D5MTG9
      Related
      ENSRNOP00000084477.2, ENSRNOT00000108697.2
      Conserved Domains (2) summary
      pfam02207
      Location:99 → 166
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:221 → 301
      ClpS; ATP-dependent Clp protease adaptor protein ClpS

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      128265160..128377830 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284367.1 → XP_063140437.1  E3 ubiquitin-protein ligase UBR1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZN6
      Related
      ENSRNOP00000015086.8, ENSRNOT00000015086.8

    2. XM_063284368.1 → XP_063140438.1  E3 ubiquitin-protein ligase UBR1 isoform X2

      UniProtKB/TrEMBL
      D3ZQC6

    3. XM_063284369.1 → XP_063140439.1  E3 ubiquitin-protein ligase UBR1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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