Naglt1 Na+ dependent glucose transporter 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Naglt1provided by RGD
Full Name: Na+ dependent glucose transporter 1provided by RGD
Primary source: RGD:631438
See related: EnsemblRapid:ENSRNOG00000000590 AllianceGenome:RGD:631438
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mfsd4b
Summary: Predicted to enable D-glucose transmembrane transporter activity. Involved in D-glucose import across plasma membrane. Located in brush border membrane. Orthologous to human MFSD4B (major facilitator superfamily domain containing 4B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 1227.1) See more
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Genomic context

Location:: 20q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (44965951..44978400, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (43411550..43423873, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (45095232..45107532, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vagal innervation appears to differentially mediate the diurnal changes in hexose transporter mRNA and protein expression in the rat jejunum by posttranscriptional, and/or posttranslational processes.
Title: The diurnal periodicity of hexose transporter mRNA and protein levels in the rat jejunum: role of vagal innervation.
role in fructose transport in rat kidney
Title: Na(+)-dependent fructose transport via rNaGLT1 in rat kidney.
Cloning and characterization of rNaGLT1 suggests it is a novel Na(+)-dependent glucose transporter with low substrate affinity that mediates kidney tubular reabsorption of glucose.
Title: Cloning and characterization of a novel Na+-dependent glucose transporter (NaGLT1) in rat kidney.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-glucose import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in hexose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sodium-dependent glucose transporter 1

Names: major facilitator superfamily domain-containing protein 4B; rNaGLT1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_176080.2 → NP_788269.1 sodium-dependent glucose transporter 1

See identical proteins and their annotated locations for NP_788269.1

Status: PROVISIONAL

Source sequence(s)

AB089802

UniProtKB/Swiss-Prot

Q4KMB5, Q80T22

UniProtKB/TrEMBL

A0A0G2JSX3, A6KIH8

Related

ENSRNOP00000054044.3, ENSRNOT00000057218.5

Conserved Domains (2) summary

cd06174
Location:43 → 450

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:46 → 413

MFS_1; Major Facilitator Superfamily