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    Lama3 laminin subunit alpha 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307582, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Lama3provided by RGD
    Official Full Name
    laminin subunit alpha 3provided by RGD
    Primary source
    RGD:628776
    See related
    EnsemblRapid:ENSRNOG00000011300 AllianceGenome:RGD:628776
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be an extracellular matrix structural constituent. Involved in cell-cell adhesion and hemidesmosome assembly. Located in adherens junction and hemidesmosome. Part of laminin-3 complex. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and lung small cell carcinoma. Orthologous to human LAMA3 (laminin subunit alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 161.0), Thymus (RPKM 49.3) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lama3 in Genome Data Viewer
    Location:
    18p13
    Exon count:
    80
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (3797898..4033021)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (3523168..3751722)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (3704866..3941215)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene NPC intracellular cholesterol transporter 1 Neighboring gene AKT interacting protein, pseudogene 1 Neighboring gene ankyrin repeat domain 29 Neighboring gene uncharacterized LOC134482906 Neighboring gene uncharacterized LOC120098332 Neighboring gene uncharacterized LOC120098331 Neighboring gene ATP synthase subunit g, mitochondrial-like Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134482905 Neighboring gene uncharacterized LOC134482904 Neighboring gene tetratricopeptide repeat domain 39C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Laminin-5 and hemidesmosomes: role of the alpha 3 chain subunit in hemidesmosome stability and assembly. Baker SE, et al. J Cell Sci, 1996 Oct. PMID 8923212
    2. Cloning of the laminin alpha 3 chain gene (LAMA3) and identification of a homozygous deletion in a patient with Herlitz junctional epidermolysis bullosa. Vidal F, et al. Genomics, 1995 Nov 20. PMID 8586427
    3. Epigenetic inactivation of laminin-5-encoding genes in lung cancers. Sathyanarayana UG, et al. Clin Cancer Res, 2003 Jul. PMID 12855645
    4. Epitope mapping of function-blocking monoclonal antibody CM6 suggests a "weak" integrin binding site on the laminin-332 LG2 domain. Yamashita H, et al. J Cell Physiol, 2010 Jun. PMID 20301201, Free PMC Article
    5. Laminin-332-beta1 integrin interactions negatively regulate invadopodia. Liu S, et al. J Cell Physiol, 2010 Apr. PMID 20039268, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Binding sites for alpha3beta1 and alpha6beta4 are closely spaced in the Ln-332 LG domains where they regulate alternative cell functions, namely adhesion/migration or hemidesmosome anchoring.
      Title: Epitope mapping of function-blocking monoclonal antibody CM6 suggests a "weak" integrin binding site on the laminin-332 LG2 domain.
    2. In bladder carcinoma laminin-332 can suppress the number of invadopodia that form by interacting with a3b1 integrin and altering the cellular balance of FAK and Src kinase activity.
      Title: Laminin-332-beta1 integrin interactions negatively regulate invadopodia.
    3. a complex of laminin alpha 3, beta3 and gamma3 chains serves as the ligand for alpha 6beta1-integrin at the apical ectoplasmic specialization in adult rat testes
      Title: Laminin alpha 3 forms a complex with beta3 and gamma3 chains that serves as the ligand for alpha 6beta1-integrin at the apical ectoplasmic specialization in adult rat testes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hemidesmosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in hemidesmosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of laminin-3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of laminin-5 complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    laminin subunit alpha-3
    Names
    laminin 5 alpha 3
    laminin, alpha 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393748.1 → NP_001380677.1  laminin subunit alpha-3 isoform B precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (B).
      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A1B0GWM3
      Related
      ENSRNOP00000075948.2, ENSRNOT00000092846.3
      Conserved Domains (9) summary
      smart00136
      Location:42 → 293
      LamNT; Laminin N-terminal domain (domain VI)
      smart00282
      Location:2434 → 2569
      LamG; Laminin G domain
      cd00055
      Location:531 → 573
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:3158 → 3309
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      TIGR02168
      Location:2031 → 2387
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06008
      Location:1846 → 2103
      Laminin_I; Laminin Domain I
      pfam06009
      Location:2287 → 2415
      Laminin_II; Laminin Domain II
      pfam00052
      Location:1517 → 1651
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:1265 → 1313
      Laminin_EGF; Laminin EGF domain

    2. NM_173306.2 → NP_775428.2  laminin subunit alpha-3 isoform A precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6KLR5, D3ZN05, P70570
      Related
      ENSRNOP00000015363.8, ENSRNOT00000015363.9
      Conserved Domains (7) summary
      smart00282
      Location:826 → 961
      LamG; Laminin G domain
      cd00055
      Location:77 → 123
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:1550 → 1701
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      TIGR02168
      Location:423 → 779
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06008
      Location:238 → 495
      Laminin_I; Laminin Domain I
      pfam06009
      Location:679 → 807
      Laminin_II; Laminin Domain II
      NF033759
      Location:18 → 216
      exchanger_TraA; outer membrane exchange protein TraA

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      3797898..4033021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096924.2 → XP_038952852.1  laminin subunit alpha-3 isoform X1

      Conserved Domains (9) summary
      smart00282
      Location:2235 → 2370
      LamG; Laminin G domain
      cd00055
      Location:332 → 374
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:2959 → 3110
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      TIGR02168
      Location:1832 → 2188
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06008
      Location:1647 → 1904
      Laminin_I; Laminin Domain I
      pfam06009
      Location:2088 → 2216
      Laminin_II; Laminin Domain II
      pfam00052
      Location:1318 → 1452
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:1066 → 1114
      Laminin_EGF; Laminin EGF domain
      cl02806
      Location:6 → 94
      Laminin_N; Laminin N-terminal (Domain VI)

    2. XM_039096925.2 → XP_038952853.1  laminin subunit alpha-3 isoform X2

      Conserved Domains (8) summary
      smart00282
      Location:1959 → 2094
      LamG; Laminin G domain
      cd00055
      Location:56 → 98
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:2683 → 2834
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      TIGR02168
      Location:1556 → 1912
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06008
      Location:1371 → 1628
      Laminin_I; Laminin Domain I
      pfam06009
      Location:1812 → 1940
      Laminin_II; Laminin Domain II
      pfam00052
      Location:1042 → 1176
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:790 → 838
      Laminin_EGF; Laminin EGF domain

    3. XM_039096926.2 → XP_038952854.1  laminin subunit alpha-3 isoform X3

      UniProtKB/TrEMBL
      A6KLR4
      Conserved Domains (8) summary
      smart00282
      Location:1510 → 1645
      LamG; Laminin G domain
      cd00055
      Location:479 → 529
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:2234 → 2385
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      TIGR02168
      Location:1107 → 1463
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06008
      Location:922 → 1179
      Laminin_I; Laminin Domain I
      pfam06009
      Location:1363 → 1491
      Laminin_II; Laminin Domain II
      pfam00052
      Location:593 → 727
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:341 → 389
      Laminin_EGF; Laminin EGF domain

    4. XM_039096927.2 → XP_038952855.1  laminin subunit alpha-3 isoform X4

      UniProtKB/TrEMBL
      A6KLR4
      Conserved Domains (8) summary
      smart00180
      Location:230 → 251
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00282
      Location:1011 → 1146
      LamG; Laminin G domain
      cd00055
      Location:262 → 308
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:1735 → 1886
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      TIGR02168
      Location:608 → 964
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06008
      Location:423 → 680
      Laminin_I; Laminin Domain I
      pfam06009
      Location:864 → 992
      Laminin_II; Laminin Domain II
      pfam00052
      Location:94 → 228
      Laminin_B; Laminin B (Domain IV)

    RNA

    1. XR_005496046.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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