Lhcgr luteinizing hormone/choriogonadotropin receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lhcgrprovided by RGD
Official Full Name: luteinizing hormone/choriogonadotropin receptorprovided by RGD
Primary source: RGD:3007
See related: EnsemblRapid:ENSRNOG00000016712 AllianceGenome:RGD:3007
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lhr; LSHR; LSH-R; LH/CG-R
Summary: Enables several functions, including ATPase binding activity; identical protein binding activity; and peptide hormone binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; activation of adenylate cyclase activity; and positive regulation of calcium ion transmembrane transport. Located in endosome and extracellular space. Part of receptor complex. Human ortholog(s) of this gene implicated in Leydig cell hypoplasia; Leydig cell tumor; breast cancer; familial male-limited precocious puberty; and gonadal disease. Orthologous to human LHCGR (luteinizing hormone/choriogonadotropin receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 193.3) and Uterus (RPKM 13.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (11415361..11480834)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (5661871..5728109)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (12493182..12554482, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association between LH receptor regulation and ovarian hyperstimulation syndrome in a rodent model.
Title: Association between LH receptor regulation and ovarian hyperstimulation syndrome in a rodent model.
The effect of clomiphene citrate and human chorionic gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as well as the structural changes in testicular tissue of adult rats.
Title: The effect of clomiphene citrate and human chorionic gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as well as the structural changes in testicular tissue of adult rats.
MiR-122 plays a regulatory role in LHCGR expression.
Title: Molecular regulation of LHCGR expression by miR-122 during follicle growth in the rat ovary.
The results of this study support the notion that by inhibiting eIF5A hypusination, FSH reduces the expression of an LHCGR mRNA-binding protein (LRBP), and then this increases LHCGR mRNA expression by abrogating the inhibitory action of LRBP.
Title: LHCGR Expression During Follicle Stimulating Hormone-Induced Follicle Growth Is Negatively Regulated by Eukaryotic Initiation Factor 5A.
these results suggest that hCG-induced LHR mRNA downregulation is mediated by cAMP-PKA-ERK1/2 signaling leading to activation of eIF5A hypusination.
Title: Hypusination of eukaryotic initiation factor 5A via cAMP-PKA-ERK1/2 pathway is required for ligand-induced downregulation of LH receptor mRNA expression in the ovary.
Demonstrate the presence of LH receptors. Activation resulted in a dose-dependent increase in glucose-induced release of insulin.
Title: The Presence of Human Chorionic Gonadotropin/Luteinizing Hormone Receptors in Pancreatic β-Cells.
interaction of NF-kappaB p65 with histone deacetylase in the promoter region of Lhcgr might be responsible for TNF-alpha action on the regulation of LH receptor
Title: TNF-α Suppressed FSH-Induced LH Receptor Expression Through Transcriptional Regulation in Rat Granulosa Cells.
miR-122 plays a regulatory role in LH/hCG-induced LHR mRNA down-regulation by increasing LRBP expression through the activation of the SREBP pathway.
Title: miR-122 Regulates LH Receptor Expression by Activating Sterol Response Element Binding Protein in Rat Ovaries.
Palmitoylated peptide 562-572 of luteinizing hormone receptor increases testosterone level in male rats.
Title: Palmitoylated peptide 562-572 of luteinizing hormone receptor increases testosterone level in male rats.
miR-136-3p participated in the down-regulation of LHR mRNA by binding directly to LHR mRNA.
Title: Role of microRNA-136-3p on the expression of luteinizing hormone-human chorionic gonadotropin receptor mRNA in rat ovaries.

Submit: New GeneRIF Correction See all GeneRIFs (44)

General gene information

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Markers

RH138460 (e-PCR)
- UniSTS:220547

Fshr (e-PCR), detects polymorphism
- UniSTS:305549

LHCGR (e-PCR)
- UniSTS:507368

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables choriogonadotropin hormone binding	IEA Inferred from Electronic Annotation more info
enables choriogonadotropin hormone binding	ISO Inferred from Sequence Orthology more info
enables choriogonadotropin hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables choriogonadotropin hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables luteinizing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables luteinizing hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables luteinizing hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables luteinizing hormone receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide hormone binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptide hormone binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in activation of adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in arachidonate secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to gonadotropin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to luteinizing hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to luteinizing hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to luteinizing hormone stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cognition	IEA Inferred from Electronic Annotation more info
involved_in cognition	ISO Inferred from Sequence Orthology more info
involved_in development of secondary male sexual characteristics	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within development of secondary male sexual characteristics	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within female gonad development	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in hormone-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in luteinizing hormone signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in luteinizing hormone signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in luteinizing hormone signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in luteinizing hormone signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within male gonad development	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	IBA Inferred from Biological aspect of Ancestor more info
involved_in ovarian follicle development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in ovulation cycle process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ovulation cycle process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ovulation cycle process	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of hormone biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inositol trisphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inositol trisphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in protein targeting to lysosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of steroid biosynthetic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of steroid hormone biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of steroid hormone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to luteinizing hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in seminiferous tubule development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within seminiferous tubule development	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in uterus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within uterus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lutropin-choriogonadotropic hormone receptor

Names: LH receptor; LH/CG receptor; luteinizing hormone receptor; luteinizing hormone/chorionic gonadotropin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433211.1 → NP_001420140.1 lutropin-choriogonadotropic hormone receptor isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_012978.3 → NP_037110.1 lutropin-choriogonadotropic hormone receptor isoform 1 precursor

See identical proteins and their annotated locations for NP_037110.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

P16235, P70646, Q63807, Q63808, Q63809, Q6LDI7

UniProtKB/TrEMBL

A6H9B2, F1LMG6

Related

ENSRNOP00000022481.6, ENSRNOT00000022481.9

Conserved Domains (3) summary

sd00033
Location:55 → 78

LRR_RI; leucine-rich repeat [structural motif]

cd15359
Location:365 → 638

7tmA_LHCGR; luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

pfam13306
Location:66 → 204

LRR_5; Leucine rich repeats (6 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

11415361..11480834

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063261562.1 → XP_063117632.1 lutropin-choriogonadotropic hormone receptor isoform X3
XM_039111807.2 → XP_038967735.1 lutropin-choriogonadotropic hormone receptor isoform X1

UniProtKB/TrEMBL

A0A8I6GK42, F1LMG6

Conserved Domains (3) summary

sd00033
Location:53 → 77

LRR_RI; leucine-rich repeat [structural motif]

cd15359
Location:339 → 612

7tmA_LHCGR; luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

pfam13306
Location:40 → 178

LRR_5; Leucine rich repeats (6 copies)
XM_039111808.2 → XP_038967736.1 lutropin-choriogonadotropic hormone receptor isoform X2

Conserved Domains (1) summary

cd15359
Location:149 → 422

7tmA_LHCGR; luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors