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    Cib1 calcium and integrin binding 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81823, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cib1provided by RGD
    Official Full Name
    calcium and integrin binding 1provided by RGD
    Primary source
    RGD:620133
    See related
    EnsemblRapid:ENSRNOG00000033498 AllianceGenome:RGD:620133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cib; Sip2-28
    Summary
    Enables protein kinase binding activity. Involved in positive regulation of calcineurin-NFAT signaling cascade. Located in axon; dendrite; and neuronal cell body. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human CIB1 (calcium and integrin binding 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 347.1), Spleen (RPKM 309.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cib1 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143587591..143593153, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (134178331..134183895, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142014962..142020461, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483744 Neighboring gene semaphorin 4B Neighboring gene GDP-D-glucose phosphorylase 1 Neighboring gene tubulin tyrosine ligase like 13 Neighboring gene neugrin, neurite outgrowth associated

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium-dependent protein kinase inhibitor activity  
    enables calcium-dependent protein kinase inhibitor activity  
    enables magnesium ion binding  
    enables protein binding PubMed 
    enables protein kinase binding PubMed 
    enables protein serine/threonine kinase inhibitor activity  
    enables protein-membrane adaptor activity  
    enables protein-membrane adaptor activity  
    enables protein-membrane adaptor activity  
    enables small GTPase binding  
    enables small GTPase binding  
    enables transmembrane transporter binding  
    enables transmembrane transporter binding  
    Items 1 - 25 of 106
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA damage response  
    involved_in DNA damage response  
    involved_in angiogenesis  
    involved_in apoptotic process  
    involved_in apoptotic process  
    involved_in apoptotic process  
    involved_in cell adhesion  
    involved_in cell differentiation  
    involved_in cell division  
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to nerve growth factor stimulus  
    involved_in cellular response to nerve growth factor stimulus  
    involved_in cellular response to nerve growth factor stimulus  
    involved_in cellular response to tumor necrosis factor  
    involved_in cellular response to tumor necrosis factor  
    involved_in cellular response to tumor necrosis factor  
    involved_in cytoplasmic microtubule organization  
    involved_in cytoplasmic microtubule organization  
    involved_in cytoplasmic microtubule organization  
    involved_in endomitotic cell cycle  
    involved_in endomitotic cell cycle  
    involved_in endomitotic cell cycle  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of megakaryocyte differentiation  
    involved_in negative regulation of megakaryocyte differentiation  
    involved_in negative regulation of megakaryocyte differentiation  
    involved_in negative regulation of microtubule depolymerization  
    involved_in negative regulation of microtubule depolymerization  
    involved_in negative regulation of microtubule depolymerization  
    involved_in negative regulation of neuron projection development  
    involved_in negative regulation of neuron projection development  
    involved_in negative regulation of neuron projection development  
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in negative regulation of protein phosphorylation  
    involved_in negative regulation of protein phosphorylation  
    involved_in platelet formation  
    involved_in platelet formation  
    involved_in platelet formation  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of calcineurin-NFAT signaling cascade  
    involved_in positive regulation of calcineurin-NFAT signaling cascade  
    involved_in positive regulation of calcineurin-NFAT signaling cascade PubMed 
    involved_in positive regulation of calcineurin-NFAT signaling cascade  
    involved_in positive regulation of catalytic activity  
    involved_in positive regulation of catalytic activity  
    involved_in positive regulation of cell adhesion mediated by integrin  
    involved_in positive regulation of cell adhesion mediated by integrin  
    involved_in positive regulation of cell adhesion mediated by integrin  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration involved in sprouting angiogenesis  
    involved_in positive regulation of cell migration involved in sprouting angiogenesis  
    involved_in positive regulation of cell migration involved in sprouting angiogenesis  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell-matrix adhesion  
    involved_in positive regulation of cell-matrix adhesion  
    involved_in positive regulation of cell-matrix adhesion  
    involved_in positive regulation of male germ cell proliferation  
    involved_in positive regulation of male germ cell proliferation  
    involved_in positive regulation of male germ cell proliferation  
    involved_in positive regulation of protein localization to plasma membrane  
    involved_in positive regulation of protein localization to plasma membrane  
    involved_in positive regulation of protein localization to plasma membrane  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of protein serine/threonine kinase activity  
    involved_in positive regulation of protein serine/threonine kinase activity  
    involved_in positive regulation of protein targeting to membrane  
    involved_in positive regulation of protein targeting to membrane  
    involved_in positive regulation of protein targeting to membrane  
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in regulation of cell division  
    involved_in regulation of cell division  
    involved_in regulation of cell division  
    involved_in regulation of cell population proliferation  
    involved_in regulation of cell population proliferation  
    involved_in response to ischemia  
    involved_in response to ischemia  
    involved_in response to ischemia  
    involved_in spermatid development  
    involved_in spermatid development  
    involved_in spermatid development  
    involved_in spermatogenesis  
    involved_in thrombopoietin-mediated signaling pathway  
    involved_in thrombopoietin-mediated signaling pathway  
    involved_in thrombopoietin-mediated signaling pathway  
    Items 1 - 25 of 106
    Items 1 - 20 of 49
    Component Evidence Code Pubs
    located_in apical plasma membrane  
    is_active_in axon  
    located_in axon PubMed 
    located_in cell periphery  
    located_in cell periphery  
    located_in centrosome  
    located_in centrosome  
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in dendrite PubMed 
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in filopodium tip  
    located_in filopodium tip  
    located_in filopodium tip  
    located_in growth cone  
    located_in growth cone  
    located_in growth cone  
    located_in lamellipodium  
    located_in lamellipodium  
    located_in lamellipodium  
    located_in membrane  
    located_in membrane  
    located_in neuron projection  
    located_in neuron projection  
    is_active_in neuronal cell body  
    located_in neuronal cell body PubMed 
    located_in neuronal cell body  
    located_in neuronal cell body  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in perikaryon  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in ruffle membrane  
    is_active_in sarcolemma  
    located_in sarcolemma  
    located_in sarcolemma  
    Items 1 - 20 of 49

    General protein information

    Preferred Names
    calcium and integrin-binding protein 1
    Names
    DNA-PKcs-interacting protein
    KIP
    calcium- and integrin-binding protein
    calmyrin
    kinase-interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031145.2NP_112407.1  calcium and integrin-binding protein 1

      See identical proteins and their annotated locations for NP_112407.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q5BKA8, Q9R010
      UniProtKB/TrEMBL
      A0A8L2QMR3, A6JC88
      Related
      ENSRNOP00000090872.1, ENSRNOT00000109833.2
      Conserved Domains (1) summary
      cd00051
      Location:111178
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      143587591..143593153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092348.2XP_038948276.1  calcium and integrin-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GD04, A6JC87
      Related
      ENSRNOP00000085326.1, ENSRNOT00000119387.2
      Conserved Domains (1) summary
      COG5126
      Location:12134
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    2. XM_039092343.2XP_038948271.1  calcium and integrin-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2I0, A0A8L2QMR3
      Related
      ENSRNOP00000085818.1, ENSRNOT00000116201.2
      Conserved Domains (1) summary
      cd00051
      Location:111178
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
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