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    Slc15a1 solute carrier family 15 member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117261, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc15a1provided by RGD
    Official Full Name
    solute carrier family 15 member 1provided by RGD
    Primary source
    RGD:621736
    See related
    EnsemblRapid:ENSRNOG00000011598 AllianceGenome:RGD:621736
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pept1
    Summary
    Enables channel inhibitor activity. Involved in metanephric proximal tubule development and negative regulation of amino acid transport. Located in apical plasma membrane. Orthologous to human SLC15A1 (solute carrier family 15 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 53.9), Testes (RPKM 6.3) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Slc15a1 in Genome Data Viewer
    Location:
    15q24
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (104944461..104991316, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (98537641..98582544, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (106800081..106844668, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482026 Neighboring gene uncharacterized LOC120097091 Neighboring gene long non-coding RNA 004 Neighboring gene uncharacterized LOC120097092 Neighboring gene dedicator of cytokinesis 9 Neighboring gene uncharacterized LOC134482163

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in dipeptide import across plasma membrane  
    involved_in dipeptide import across plasma membrane  
    involved_in dipeptide import across plasma membrane  
    involved_in dipeptide import across plasma membrane  
    involved_in metanephric proximal tubule development PubMed 
    involved_in negative regulation of amino acid transport PubMed 
    involved_in oligopeptide transport  
    acts_upstream_of_or_within oligopeptide transport  
    involved_in protein transport  
    involved_in proton transmembrane transport  
    involved_in transmembrane transport  
    involved_in tripeptide transport  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane  
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in brush border  
    located_in brush border  
    located_in membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    solute carrier family 15 member 1
    Names
    intestinal H(+)/peptide cotransporter
    peptide transporter 1
    pineal gland-specific PEPT1
    proton-coupled dipeptide cotransporter
    solute carrier family 15 (oligopeptide transporter), member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079838.1NP_001073307.1  solute carrier family 15 member 1 isoform pgPepT1

      See identical proteins and their annotated locations for NP_001073307.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) lacks alternate exons in the 5' UTR and 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (pgPepT1) has a distinct N-terminus and is shorter than isoform PepT1.
      Source sequence(s)
      AY860424
      UniProtKB/Swiss-Prot
      P51574
      Conserved Domains (1) summary
      cl21472
      Location:1174
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    2. NM_057121.2NP_476462.2  solute carrier family 15 member 1 isoform PepT1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (PepT1).
      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      P51574, Q5EML1
      UniProtKB/TrEMBL
      A6HUK3, F1LMZ1
      Related
      ENSRNOP00000015890.7, ENSRNOT00000015890.8
      Conserved Domains (1) summary
      TIGR00926
      Location:28672
      2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      104944461..104991316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_010057796.1 RNA Sequence

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