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    Ctrb1 chymotrypsinogen B1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24291, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ctrb1provided by RGD
    Official Full Name
    chymotrypsinogen B1provided by RGD
    Primary source
    RGD:2444
    See related
    EnsemblRapid:ENSRNOG00000019068 AllianceGenome:RGD:2444
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ctrb
    Summary
    Enables serine-type endopeptidase activity. Involved in several processes, including positive regulation of apoptotic process; response to food; and response to peptide hormone. Predicted to be located in extracellular region. Biomarker of pancreatitis. Orthologous to several human genes including CTRB2 (chymotrypsinogen B2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 8368.4) and Liver (RPKM 2618.4) See more
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    Genomic context

    See Ctrb1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (56562220..56566978, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (39652931..39657689, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (43906344..43911020, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase D Neighboring gene zinc finger protein 1 Neighboring gene BCAR1 scaffold protein, Cas family member Neighboring gene uncharacterized LOC134483372 Neighboring gene craniofacial development protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables peptidase activity  
    enables protein binding PubMed 
    enables serine-type endopeptidase activity  
    enables serine-type endopeptidase activity PubMed 
    enables serine-type endopeptidase activity  
    enables serine-type endopeptidase activity  
    enables serine-type peptidase activity  
    Process Evidence Code Pubs
    involved_in digestion  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in protein catabolic process PubMed 
    involved_in proteolysis  
    involved_in proteolysis  
    acts_upstream_of_or_within proteolysis  
    involved_in response to cytokine PubMed 
    involved_in response to food PubMed 
    involved_in response to nutrient PubMed 
    involved_in response to peptide hormone PubMed 
    involved_in response to toxic substance PubMed 
    Component Evidence Code Pubs
    located_in extracellular region  

    General protein information

    Preferred Names
    chymotrypsinogen B
    Names
    Chymotrypsin B
    chymotrypsin B1
    NP_036668.2
    XP_038953395.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012536.2NP_036668.2  chymotrypsinogen B precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      P07338
      UniProtKB/TrEMBL
      F1MA56
      Related
      ENSRNOP00000026017.1, ENSRNOT00000026017.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      56562220..56566978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097467.2XP_038953395.1  chymotrypsinogen B isoform X1

      Conserved Domains (1) summary
      cd00190
      Location:3146
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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