Akr1b8 aldo-keto reductase family 1, member B8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Akr1b8provided by RGD
Official Full Name: aldo-keto reductase family 1, member B8provided by RGD
Primary source: RGD:708475
See related: EnsemblRapid:ENSRNOG00000027433 AllianceGenome:RGD:708475
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable aldose reductase (NADPH) activity and estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Orthologous to human AKR1B10 (aldo-keto reductase family 1 member B10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 5569.0) and Kidney (RPKM 242.2) See more
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Genomic context

Location:: 4q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (63964421..63976995)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (62997241..63009815)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (61772064..61784637)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The crystal structure of the binary complex aldose reductase-like protein-NADPH was determined at 1.86A resolution.
Title: Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aldose reductase-related protein 2

Names: aldose reductase-like protein

NP_775159.1

EC 1.1.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173136.1 → NP_775159.1 aldose reductase-related protein 2

See identical proteins and their annotated locations for NP_775159.1

Status: PROVISIONAL

Source sequence(s)

AJ277957

UniProtKB/TrEMBL

A6IEL7, Q91W30

Related

ENSRNOP00000013073.4, ENSRNOT00000013073.6

Conserved Domains (2) summary

COG0656
Location:1 → 297

ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

COG0667
Location:16 → 289

Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]