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    Brd2 bromodomain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294276, updated on 9-Dec-2024

    Summary

    Symbol
    Brd2provided by RGD
    Full Name
    bromodomain containing 2provided by RGD
    Primary source
    RGD:1303324
    See related
    EnsemblRapid:ENSRNOG00000000461 AllianceGenome:RGD:1303324
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ring3
    Summary
    Predicted to enable chromatin binding activity; lysine-acetylated histone binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including chromatin looping; nucleosome assembly; and positive regulation of T-helper 17 cell lineage commitment. Predicted to act upstream of or within neural tube closure. Predicted to be located in chromatin; cytoplasm; and nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 337.6), Testes (RPKM 264.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Brd2 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4728282..4737286)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4727078..4735389)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3910555..3921074, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene RT1 class II, locus DMa Neighboring gene bromodomain containing 2 like Neighboring gene RT1 class II, locus DOa Neighboring gene RT1 class II, locus Ha

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acetylation-dependent protein binding  
    enables chromatin binding  
    enables chromatin binding  
    enables lysine-acetylated histone binding  
    enables lysine-acetylated histone binding  
    enables lysine-acetylated histone binding  
    enables protein serine/threonine kinase activity  
    Process Evidence Code Pubs
    involved_in chromatin looping  
    involved_in chromatin looping  
    involved_in chromatin organization  
    involved_in chromatin remodeling  
    acts_upstream_of_or_within neural tube closure  
    involved_in nucleosome assembly  
    involved_in nucleosome assembly  
    involved_in positive regulation of T-helper 17 cell lineage commitment  
    involved_in positive regulation of T-helper 17 cell lineage commitment  
    involved_in protein localization to chromatin  
    involved_in protein localization to chromatin  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of gene expression  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    Component Evidence Code Pubs
    located_in chromatin  
    is_active_in chromatin  
    located_in chromosome  
    located_in cytoplasm  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    bromodomain-containing protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212495.1NP_997660.1  bromodomain-containing protein 2

      See identical proteins and their annotated locations for NP_997660.1

      Status: VALIDATED

      Source sequence(s)
      BX883042
      UniProtKB/Swiss-Prot
      Q6MGA9
      UniProtKB/TrEMBL
      A0A8I5ZYL9, A6JJF0
      Conserved Domains (4) summary
      cd05497
      Location:73179
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:348449
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      PHA03247
      Location:215332
      PHA03247; large tegument protein UL36; Provisional
      pfam17035
      Location:639701
      BET; Bromodomain extra-terminal - transcription regulation

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      4728282..4737286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279018.1XP_063135088.1  bromodomain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6MGA9
      UniProtKB/TrEMBL
      A0A8I5ZYL9, A6JJF0
    2. XM_017601578.3XP_017457067.1  bromodomain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6MGA9
      UniProtKB/TrEMBL
      A0A8I5ZYL9, A6JJF0
      Related
      ENSRNOP00000098184.1, ENSRNOT00000120531.2
      Conserved Domains (4) summary
      cd05497
      Location:73179
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:348449
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      PHA03247
      Location:215332
      PHA03247; large tegument protein UL36; Provisional
      pfam17035
      Location:639701
      BET; Bromodomain extra-terminal - transcription regulation
    3. XM_039098498.2XP_038954426.1  bromodomain-containing protein 2 isoform X4

      Conserved Domains (3) summary
      cd05497
      Location:73179
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      PHA03247
      Location:215332
      PHA03247; large tegument protein UL36; Provisional
      cl02556
      Location:348400
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    4. XM_008772772.4XP_008770994.1  bromodomain-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_008770994.1

      UniProtKB/TrEMBL
      A0A8I5ZYL9
      Related
      ENSRNOP00000082798.3, ENSRNOT00000060194.7
      Conserved Domains (3) summary
      cd05497
      Location:27133
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:302403
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:593657
      BET; Bromodomain extra-terminal - transcription regulation
    5. XM_063279019.1XP_063135089.1  bromodomain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K1Z8, A0A8I5ZYL9
      Related
      ENSRNOP00000072049.4, ENSRNOT00000080585.4
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