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    Kif18b kinesin family member 18B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303575, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kif18bprovided by RGD
    Official Full Name
    kinesin family member 18Bprovided by RGD
    Primary source
    RGD:1310360
    See related
    EnsemblRapid:ENSRNOG00000021713 AllianceGenome:RGD:1310360
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310360
    Summary
    Predicted to enable ATP hydrolysis activity; cytoskeletal protein binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in several processes, including microtubule depolymerization; mitotic sister chromatid segregation; and regulation of cell division. Predicted to be located in cytosol; microtubule; and nuclear body. Predicted to be part of kinesin complex. Predicted to be active in mitotic spindle astral microtubule; mitotic spindle midzone; and nucleus. Orthologous to human KIF18B (kinesin family member 18B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 66.9), Spleen (RPKM 53.6) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kif18b in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (88370520..88392388, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87870424..87889895, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (91008294..91027760, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene elongation factor Tu GTP binding domain containing 2 Neighboring gene family with sequence similarity 187, member A Neighboring gene glial fibrillary acidic protein Neighboring gene ribosomal protein L22 like 4 Neighboring gene complement C1q like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC116269

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytoskeletal motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in astral microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule end ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitotic spindle astral microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in mitotic spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    kinesin-like protein KIF18B
    Names
    kinesin-like protein KIF18B-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039019.1NP_001034108.1  kinesin-like protein KIF18B

      See identical proteins and their annotated locations for NP_001034108.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099126
      UniProtKB/Swiss-Prot
      Q4KLL9
      UniProtKB/TrEMBL
      A0A8L2R323
      Conserved Domains (2) summary
      smart00129
      Location:18360
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01370
      Location:18353
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      88370520..88392388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247505.5XP_006247567.1  kinesin-like protein KIF18B isoform X2

      See identical proteins and their annotated locations for XP_006247567.1

      UniProtKB/Swiss-Prot
      Q4KLL9
      UniProtKB/TrEMBL
      A0A8L2R323
      Conserved Domains (2) summary
      smart00129
      Location:18360
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01370
      Location:18353
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
    2. XM_008768283.4XP_008766505.1  kinesin-like protein KIF18B isoform X1

      UniProtKB/TrEMBL
      A0A8L2R323
      Related
      ENSRNOP00000034491.4, ENSRNOT00000032339.6
      Conserved Domains (2) summary
      smart00129
      Location:18360
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01370
      Location:18353
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup