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    Pip4k2b phosphatidylinositol-5-phosphate 4-kinase type 2 beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 89812, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pip4k2bprovided by RGD
    Official Full Name
    phosphatidylinositol-5-phosphate 4-kinase type 2 betaprovided by RGD
    Primary source
    RGD:621710
    See related
    EnsemblRapid:ENSRNOG00000013030 AllianceGenome:RGD:621710
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pip5k2b
    Summary
    Predicted to enable phosphatidylinositol kinase activity; protein homodimerization activity; and purine ribonucleoside triphosphate binding activity. Predicted to be involved in several processes, including 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; autophagosome-lysosome fusion; and positive regulation of autophagosome assembly. Predicted to act upstream of or within phosphatidylinositol metabolic process. Predicted to be located in autophagosome and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human PIP4K2B (phosphatidylinositol-5-phosphate 4-kinase type 2 beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 179.0), Muscle (RPKM 169.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pip4k2b in Genome Data Viewer
    Location:
    10q31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83202379..83231292, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82706016..82734938, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85655223..85684138, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit beta 3 Neighboring gene transfer RNA threonine (anticodon AGU) 11 Neighboring gene CWC25 spliceosome-associated protein homolog Neighboring gene transfer RNA cysteine (anticodon GCA) 33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel phosphatidylinositol-5-phosphate 4-kinase (phosphatidylinositol-phosphate kinase IIgamma) is phosphorylated in the endoplasmic reticulum in response to mitogenic signals. Itoh T, et al. J Biol Chem, 1998 Aug 7. PMID 9685379
    2. Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. Rao VD, et al. Cell, 1998 Sep 18. PMID 9753329
    3. A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. Castellino AM, et al. J Biol Chem, 1997 Feb 28. PMID 9038203
    4. The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site. Clarke JH, et al. Biochem J, 2015 Mar 1. PMID 25495341, Free PMC Article
    5. Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization. Clarke JH, et al. Biochem J, 2013 Aug 15. PMID 23758345, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 1-phosphatidylinositol-5-phosphate 4-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in autophagosome-lysosome fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagosome-lysosome fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagosome-lysosome fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol 5-phosphate 4-kinase type-2 beta
    Names
    1-phosphatidylinositol 5-phosphate 4-kinase 2-beta
    1-phosphatidylinositol-5-phosphate 4-kinase B
    PI(5)P 4-kinase type II beta
    PIP4KII-beta
    PIPKIIgamma
    diphosphoinositide kinase 2-beta
    phosphatidylinositol 5-phosphate 4-kinase type II beta
    phosphatidylinositol-4-phosphate 5-kinase, type II, beta
    phosphatidylinositol-phosphate kinase IIgamma
    NP_446002.1
    XP_008766353.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053550.2 → NP_446002.1  phosphatidylinositol 5-phosphate 4-kinase type-2 beta

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O88377
      UniProtKB/TrEMBL
      A0A8I6A493, A6HIM4
      Related
      ENSRNOP00000017989.3, ENSRNOT00000017989.5
      Conserved Domains (1) summary
      cd17310
      Location:30 → 413
      PIPKc_PIP5K2B; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP5K2B) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      83202379..83231292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768131.4 → XP_008766353.1  phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1

      Conserved Domains (1) summary
      smart00330
      Location:3 → 351
      PIPKc; Phosphatidylinositol phosphate kinases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88377.1 GenPept UniProtKB/Swiss-Prot:O88377

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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