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    Sbsn suprabasin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292793, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sbsnprovided by RGD
    Official Full Name
    suprabasinprovided by RGD
    Primary source
    RGD:1562305
    See related
    EnsemblRapid:ENSRNOG00000021015 AllianceGenome:RGD:1562305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562305
    Summary
    Predicted to be located in cytoplasm. Orthologous to human SBSN (suprabasin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 59.3), Adrenal (RPKM 28.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sbsn in Genome Data Viewer
    Location:
    1q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95106390..95133448)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85978970..86006034)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89202527..89206994)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ATPase H+/K+ transporting subunit alpha Neighboring gene transmembrane protein 147 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Neighboring gene dermokine Neighboring gene keratinocyte differentiation associated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Suprabasin, a novel epidermal differentiation marker and potential cornified envelope precursor. Park GT, et al. J Biol Chem, 2002 Nov 22. PMID 12228223, Free PMC Article
    2. SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Zanivan S, et al. Mol Cell Proteomics, 2013 Dec. PMID 23979707, Free PMC Article
    3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC125085

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    suprabasin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044231.2 → NP_001037696.1  suprabasin isoform 2 precursor

      See identical proteins and their annotated locations for NP_001037696.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splicing site in the CDS, as compared to variant 1. The resulting isoform (2) is much shorter and lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      BC107924, CV112367, JAXUCZ010000001
      UniProtKB/TrEMBL
      Q32PY8

    2. NM_001198590.1 → NP_001185519.1  suprabasin isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      F7FEM5
      Related
      ENSRNOP00000084464.2, ENSRNOT00000111530.2
      Conserved Domains (1) summary
      NF033849
      Location:138 → 418
      ser_rich_anae_1; serine-rich protein

    3. NM_001198591.1 → NP_001185520.1  suprabasin isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate splicing site in the CDS, as compared to variant 1. The resulting isoform (3) is much shorter and lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      BC157808, JAXUCZ010000001

    RNA

    1. NR_177078.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate upstream promoter compared to variants 1-3 and is predicted to be non-coding.
      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      95106390..95133448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104509.2 → XP_038960437.1  suprabasin isoform X3

      UniProtKB/TrEMBL
      Q32PY8

    2. XM_063283652.1 → XP_063139722.1  suprabasin isoform X1

      Related
      ENSRNOP00000099167.1, ENSRNOT00000133127.1

    3. XM_063283656.1 → XP_063139726.1  suprabasin isoform X2

      UniProtKB/TrEMBL
      F7FEM5

    4. XM_063283654.1 → XP_063139724.1  suprabasin isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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