Dock7 dedicator of cytokinesis 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dock7provided by RGD
Official Full Name: dedicator of cytokinesis 7provided by RGD
Primary source: RGD:1309790
See related: EnsemblRapid:ENSRNOG00000008298 AllianceGenome:RGD:1309790
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including activation of GTPase activity; negative regulation of cold-induced thermogenesis; and nervous system development. Predicted to act upstream of or within hematopoietic progenitor cell differentiation and pigmentation. Predicted to be part of COP9 signalosome. Predicted to be active in neuromuscular junction. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 23. Orthologous to human DOCK7 (dedicator of cytokinesis 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 129.9), Heart (RPKM 123.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q33

Exon count:: 51

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (118714863..118898362, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (113599371..113782871, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (117595194..117780844, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells.
Title: Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells.
in PC12 cells MVI-Dock7 complexes may function at different cellular locations during the entire cell cycle. Of note, MVI and Dock7 colocalized in primary culture hippocampal neurons also, predominantly in the outgrowths
Title: Dock7: a GEF for Rho-family GTPases and a novel myosin VI-binding partner in neuronal PC12 cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129449 (e-PCR)
- UniSTS:212755

RH131293 (e-PCR)
- UniSTS:214576

AL009364 (e-PCR)
- UniSTS:15687

RH135495 (e-PCR)
- UniSTS:209822

BF386383 (e-PCR)
- UniSTS:243698

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in establishment of neuroblast polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in interkinetic nuclear migration	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pigmentation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic specialization assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dedicator of cytokinesis protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415885.1 → NP_001402814.1 dedicator of cytokinesis protein 7 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A0G2K3H2, A0A8I6ACL2

Related

ENSRNOP00000089895.2, ENSRNOT00000100273.2
NM_001415886.1 → NP_001402815.1 dedicator of cytokinesis protein 7 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

F6PUC8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

118714863..118898362 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287647.1 → XP_063143717.1 dedicator of cytokinesis protein 7 isoform X5

UniProtKB/TrEMBL

A0A8I6ACL2
XM_063287651.1 → XP_063143721.1 dedicator of cytokinesis protein 7 isoform X9

UniProtKB/TrEMBL

F6PUC8
XM_063287646.1 → XP_063143716.1 dedicator of cytokinesis protein 7 isoform X4

UniProtKB/TrEMBL

F6PUC8
XM_063287644.1 → XP_063143714.1 dedicator of cytokinesis protein 7 isoform X2

UniProtKB/TrEMBL

F6PUC8

Related

ENSRNOP00000063286.3, ENSRNOT00000065112.4
XM_063287645.1 → XP_063143715.1 dedicator of cytokinesis protein 7 isoform X3

UniProtKB/TrEMBL

F6PUC8

Related

ENSRNOP00000098970.1, ENSRNOT00000156393.1
XM_063287643.1 → XP_063143713.1 dedicator of cytokinesis protein 7 isoform X1

UniProtKB/TrEMBL

A0A8I6ACL2

Related

ENSRNOP00000072637.3, ENSRNOT00000081971.3
XM_063287649.1 → XP_063143719.1 dedicator of cytokinesis protein 7 isoform X7
XM_063287648.1 → XP_063143718.1 dedicator of cytokinesis protein 7 isoform X6
XM_063287650.1 → XP_063143720.1 dedicator of cytokinesis protein 7 isoform X8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001191574.2: Suppressed sequence

Description

NM_001191574.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.