Lrg1 leucine-rich alpha-2-glycoprotein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrg1provided by RGD
Official Full Name: leucine-rich alpha-2-glycoprotein 1provided by RGD
Primary source: RGD:1359464
See related: AllianceGenome:RGD:1359464
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including potassium channel activator activity; transforming growth factor beta receptor binding activity; and transmembrane transporter binding activity. Predicted to be involved in positive regulation of epithelial to mesenchymal transition. Predicted to act upstream of or within several processes, including brown fat cell differentiation; positive regulation of transforming growth factor beta receptor signaling pathway; and wound healing, spreading of epidermal cells. Predicted to be located in extracellular space and intracellular membrane-bounded organelle. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human LRG1 (leucine rich alpha-2-glycoprotein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 179.8), Lung (RPKM 55.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (1034691..1036937, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (947516..949773, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (10952424..10954664)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-497 elevation or LRG1 knockdown promotes osteoblast proliferation and collagen synthesis in osteoporosis via TGF-beta1/Smads signalling pathway.
Title: MicroRNA-497 elevation or LRG1 knockdown promotes osteoblast proliferation and collagen synthesis in osteoporosis via TGF-β1/Smads signalling pathway.
Culture of slices in lower glucose concentration was associated with lower Lrg1 methylation
Title: Alterations in glucose concentrations affect DNA methylation at Lrg1 in an ex vivo rat cortical slice model of preterm brain injury.
LRG1 may promote angiogenesis through upregulating the TGFbeta1 signaling pathway in ischemic rat brain following MCAO.
Title: LRG1 promotes angiogenesis through upregulating the TGF‑β1 pathway in ischemic rat brain.

Submit: New GeneRIF Correction

General gene information

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Markers

D2Wox59 (e-PCR)
- UniSTS:240056

RH135075 (e-PCR)
- UniSTS:218352

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables potassium channel activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables type I transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info
enables type II transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of keratinocyte migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of leukocyte adhesion to vascular endothelial cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of epithelial cell proliferation involved in wound healing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within wound healing, spreading of epidermal cells	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leucine-rich alpha-2-glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009717.1 → NP_001009717.1 leucine-rich alpha-2-glycoprotein precursor

See identical proteins and their annotated locations for NP_001009717.1

Status: PROVISIONAL

Source sequence(s)

BC088434

UniProtKB/TrEMBL

M0R8H5, Q5I0E1

Conserved Domains (4) summary

smart00082
Location:282 → 328

LRRCT; Leucine rich repeat C-terminal domain

cd00116
Location:23 → 284

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:55 → 76

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:75 → 135

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

1034691..1036937 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084024.2 → XP_038939952.1 leucine-rich alpha-2-glycoprotein isoform X1

UniProtKB/TrEMBL

A6KQZ8, M0R8H5

Conserved Domains (3) summary

PRK15370
Location:55 → 293

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:259 → 339

PCC; polycystin cation channel protein

sd00033
Location:65 → 86

LRR_RI; leucine-rich repeat [structural motif]