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    Hectd3 HECT domain E3 ubiquitin protein ligase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313525, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hectd3provided by RGD
    Official Full Name
    HECT domain E3 ubiquitin protein ligase 3provided by RGD
    Primary source
    RGD:1309823
    See related
    EnsemblRapid:ENSRNOG00000018363 AllianceGenome:RGD:1309823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309823
    Summary
    Predicted to enable syntaxin binding activity and ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in perinuclear region of cytoplasm. Orthologous to human HECTD3 (HECT domain E3 ubiquitin protein ligase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 70.9), Brain (RPKM 62.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hectd3 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (135706437..135715173)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (130469840..130479802)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135860578..135870535)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene zinc finger, SWIM-type containing 5 Neighboring gene large ribosomal subunit protein eL18-like Neighboring gene 40S ribosomal protein S12-like Neighboring gene uroporphyrinogen decarboxylase Neighboring gene eukaryotic translation initiation factor 2B subunit gamma Neighboring gene small ribosomal subunit protein uS10-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. HECTD3 promotes NLRP3 inflammasome and pyroptosis to exacerbate diabetes-related cognitive impairment by stabilising MALT1 to regulate JNK pathway. Ruan Z, et al. Arch Physiol Biochem, 2024 Aug. PMID 35913790
    2. The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara. Yu J, et al. Biochem Biophys Res Commun, 2008 Mar 21. PMID 18194665
    3. Interaction between syntaxin 8 and HECTd3, a HECT domain ligase. Zhang L, et al. Cell Mol Neurobiol, 2009 Feb. PMID 18821010
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HECTD3 promotes NLRP3 inflammasome and pyroptosis to exacerbate diabetes-related cognitive impairment by stabilising MALT1 to regulate JNK pathway.
      Title: HECTD3 promotes NLRP3 inflammasome and pyroptosis to exacerbate diabetes-related cognitive impairment by stabilising MALT1 to regulate JNK pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HECTD3
    Names
    HECT domain containing E3 ubiquitin protein ligase 3
    NP_001386141.1
    XP_038967444.1
    XP_038967445.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399212.1 → NP_001386141.1  E3 ubiquitin-protein ligase HECTD3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      F1LVZ9
      Related
      ENSRNOP00000024737.7, ENSRNOT00000024737.9
      Conserved Domains (2) summary
      cd08666
      Location:238 → 371
      APC10-HECTD3; APC10-like DOC1 domain of HECTD3, a HECT E3 ubiquitin ligase protein that mediates substrate ubiquitination
      pfam00632
      Location:579 → 845
      HECT; HECT-domain (ubiquitin-transferase)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      135706437..135715173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111516.2 → XP_038967444.1  E3 ubiquitin-protein ligase HECTD3 isoform X1

      Conserved Domains (2) summary
      cd08666
      Location:238 → 371
      APC10-HECTD3; APC10-like DOC1 domain of HECTD3, a HECT E3 ubiquitin ligase protein that mediates substrate ubiquitination
      cl27008
      Location:579 → 646
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    2. XM_039111517.2 → XP_038967445.1  E3 ubiquitin-protein ligase HECTD3 isoform X2

      Conserved Domains (2) summary
      cl02148
      Location:1 → 66
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      pfam00632
      Location:281 → 540
      HECT; HECT-domain (ubiquitin-transferase)

    RNA

    1. XR_592703.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
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