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    Sez6l2 seizure related 6 homolog like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308988, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sez6l2provided by RGD
    Official Full Name
    seizure related 6 homolog like 2provided by RGD
    Primary source
    RGD:1565281
    See related
    EnsemblRapid:ENSRNOG00000027098 AllianceGenome:RGD:1565281
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565281
    Summary
    Predicted to be involved in regulation of protein kinase C signaling and synapse maturation. Predicted to act upstream of or within adult locomotory behavior and cerebellar Purkinje cell layer development. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum and neuronal cell body. Orthologous to human SEZ6L2 (seizure related 6 homolog like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 150.5), Adrenal (RPKM 14.9) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sez6l2 in Genome Data Viewer
    Location:
    1q37
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190987647..191007990)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181557109..181577456)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198383201..198403544)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 13 Neighboring gene aspartate beta-hydroxylase domain containing 1 Neighboring gene CDIP transferase, opposite strand Neighboring gene CDP-diacylglycerol--inositol 3-phosphatidyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. Miyazaki T, et al. FEBS Lett, 2006 Jul 24. PMID 16814779
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within activation of protein kinase C activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebellar Purkinje cell layer development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein kinase C signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within synapse maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    seizure 6-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107550.2 → NP_001101020.1  seizure 6-like protein 2 precursor

      See identical proteins and their annotated locations for NP_001101020.1

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I9J3, D4A6P1
      Related
      ENSRNOP00000035589.3, ENSRNOT00000037405.5
      Conserved Domains (4) summary
      cd00033
      Location:290 → 345
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:665 → 828
      PHA02927; secreted complement-binding protein; Provisional
      cd00041
      Location:527 → 617
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00084
      Location:466 → 523
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      190987647..191007990
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230264.2 → XP_006230326.1  seizure 6-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQG6
      Related
      ENSRNOP00000080735.1, ENSRNOT00000118351.2
      Conserved Domains (4) summary
      cd00033
      Location:290 → 345
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:665 → 828
      PHA02927; secreted complement-binding protein; Provisional
      cd00041
      Location:527 → 617
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00084
      Location:466 → 523
      Sushi; Sushi repeat (SCR repeat)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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