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    Wnk2 WNK lysine deficient protein kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306811, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wnk2provided by RGD
    Official Full Name
    WNK lysine deficient protein kinase 2provided by RGD
    Primary source
    RGD:1307284
    See related
    EnsemblRapid:ENSRNOG00000016684 AllianceGenome:RGD:1307284
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307284
    Summary
    Predicted to enable potassium channel inhibitor activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including protein autophosphorylation; regulation of metal ion transport; and regulation of signal transduction. Predicted to be active in cytosol. Biomarker of transient cerebral ischemia. Orthologous to human WNK2 (WNK lysine deficient protein kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 48.5), Muscle (RPKM 36.0) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wnk2 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (15709648..15818874)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (15503672..15612479)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (15923508..16032271)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain family, member 19 Neighboring gene ninjurin 1 Neighboring gene transfer RNA alanine (anticodon UGC) 8 Neighboring gene uncharacterized LOC134482822

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CircRNA-WNK2 Acts as a ceRNA for miR-328a-3p to Promote AANAT Expression in the Male Rat Pineal Gland. Zheng Y, et al. Endocrinology, 2022 Feb 1. PMID 34918065
    2. Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2. Moniz S, et al. Oncogene, 2007 Sep 6. PMID 17667937
    3. WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. Bhuiyan MIH, et al. J Cereb Blood Flow Metab, 2017 Aug. PMID 27798271, Free PMC Article
    4. WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. Rinehart J, et al. J Biol Chem, 2011 Aug 26. PMID 21733846, Free PMC Article
    5. Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling. Serysheva E, et al. EMBO Rep, 2013 Aug. PMID 23797875, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircRNA-WNK2 Acts as a ceRNA for miR-328a-3p to Promote AANAT Expression in the Male Rat Pineal Gland.
      Title: CircRNA-WNK2 Acts as a ceRNA for miR-328a-3p to Promote AANAT Expression in the Male Rat Pineal Gland.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase WNK2
    Names
    kinase deficient protein
    NP_001178485.1
    XP_006253777.1
    XP_017456004.1
    XP_017456005.1
    XP_038951586.1
    XP_038951593.1
    XP_063132425.1
    XP_063132426.1
    XP_063132427.1
    XP_063132428.1
    XP_063132429.1
    XP_063132430.1
    XP_063132431.1
    XP_063132432.1
    XP_063132433.1
    XP_063132434.1
    XP_063132435.1
    XP_063132436.1
    XP_063132437.1
    XP_063132438.1
    XP_063132439.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191556.1 → NP_001178485.1  serine/threonine-protein kinase WNK2

      See identical proteins and their annotated locations for NP_001178485.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      D3ZMJ7
      Related
      ENSRNOP00000039118.5, ENSRNOT00000050696.7
      Conserved Domains (3) summary
      PHA03247
      Location:700 → 1085
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      15709648..15818874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276357.1 → XP_063132427.1  serine/threonine-protein kinase WNK2 isoform X4

      UniProtKB/TrEMBL
      D3ZMJ7

    2. XM_063276358.1 → XP_063132428.1  serine/threonine-protein kinase WNK2 isoform X8

      UniProtKB/TrEMBL
      D3ZMJ7

    3. XM_063276356.1 → XP_063132426.1  serine/threonine-protein kinase WNK2 isoform X3

      UniProtKB/TrEMBL
      D3ZMJ7

    4. XM_063276355.1 → XP_063132425.1  serine/threonine-protein kinase WNK2 isoform X2

      UniProtKB/TrEMBL
      D3ZMJ7

    5. XM_063276362.1 → XP_063132432.1  serine/threonine-protein kinase WNK2 isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZRK5

    6. XM_063276359.1 → XP_063132429.1  serine/threonine-protein kinase WNK2 isoform X9

      UniProtKB/TrEMBL
      D3ZMJ7

    7. XM_006253715.5 → XP_006253777.1  serine/threonine-protein kinase WNK2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AC38, D3ZMJ7
      Conserved Domains (3) summary
      smart00220
      Location:200 → 453
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 511
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    8. XM_063276364.1 → XP_063132434.1  serine/threonine-protein kinase WNK2 isoform X15

      UniProtKB/TrEMBL
      D3ZMJ7

    9. XM_063276367.1 → XP_063132437.1  serine/threonine-protein kinase WNK2 isoform X18

      UniProtKB/TrEMBL
      A0A8I5ZRK5

    10. XM_063276369.1 → XP_063132439.1  serine/threonine-protein kinase WNK2 isoform X20

      UniProtKB/TrEMBL
      A0A8I5ZRK5

    11. XM_063276361.1 → XP_063132431.1  serine/threonine-protein kinase WNK2 isoform X11

      UniProtKB/TrEMBL
      D3ZMJ7

    12. XM_039095658.2 → XP_038951586.1  serine/threonine-protein kinase WNK2 isoform X5

      UniProtKB/TrEMBL
      D3ZMJ7
      Conserved Domains (3) summary
      PHA03247
      Location:700 → 1085
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    13. XM_063276363.1 → XP_063132433.1  serine/threonine-protein kinase WNK2 isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZXV8, D3ZMJ7
      Related
      ENSRNOP00000084430.1, ENSRNOT00000115946.2

    14. XM_039095665.2 → XP_038951593.1  serine/threonine-protein kinase WNK2 isoform X14

      UniProtKB/TrEMBL
      D3ZMJ7
      Conserved Domains (3) summary
      PHA03247
      Location:700 → 1085
      PHA03247; large tegument protein UL36; Provisional
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 537
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    15. XM_063276366.1 → XP_063132436.1  serine/threonine-protein kinase WNK2 isoform X17

      UniProtKB/TrEMBL
      A0A8I5ZRK5
      Related
      ENSRNOP00000081251.2, ENSRNOT00000094776.2

    16. XM_017600516.3 → XP_017456005.1  serine/threonine-protein kinase WNK2 isoform X7

      UniProtKB/TrEMBL
      D3ZMJ7
      Related
      ENSRNOP00000079712.2, ENSRNOT00000117530.2
      Conserved Domains (3) summary
      smart00220
      Location:200 → 453
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 511
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    17. XM_063276360.1 → XP_063132430.1  serine/threonine-protein kinase WNK2 isoform X10

      UniProtKB/TrEMBL
      A0A8I6APM9, D3ZMJ7
      Related
      ENSRNOP00000096453.1, ENSRNOT00000117974.2

    18. XM_063276365.1 → XP_063132435.1  serine/threonine-protein kinase WNK2 isoform X16

      UniProtKB/TrEMBL
      D3ZMJ7

    19. XM_017600515.3 → XP_017456004.1  serine/threonine-protein kinase WNK2 isoform X6

      UniProtKB/TrEMBL
      A0A0G2KAS8, D3ZMJ7
      Related
      ENSRNOP00000075510.2, ENSRNOT00000084304.3
      Conserved Domains (3) summary
      smart00220
      Location:200 → 453
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14032
      Location:193 → 458
      STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
      pfam12202
      Location:474 → 511
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    20. XM_063276368.1 → XP_063132438.1  serine/threonine-protein kinase WNK2 isoform X19

      UniProtKB/TrEMBL
      A0A8I5ZP34
    Nucleotide Protein Strain
    Heading Accession and Version

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