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    Ibtk inhibitor of Bruton tyrosine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315858, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ibtkprovided by RGD
    Official Full Name
    inhibitor of Bruton tyrosine kinaseprovided by RGD
    Primary source
    RGD:1311697
    See related
    EnsemblRapid:ENSRNOG00000027728 AllianceGenome:RGD:1311697
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein kinase binding activity and protein tyrosine kinase inhibitor activity. Predicted to be involved in release of sequestered calcium ion into cytosol. Predicted to act upstream of or within negative regulation of protein phosphorylation. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human IBTK (inhibitor of Bruton tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 244.0), Spleen (RPKM 186.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ibtk in Genome Data Viewer
    Location:
    8q31
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (95505630..95579435, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (86625591..86698661, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (93323454..93397044, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene terminal nucleotidyltransferase 5A Neighboring gene uncharacterized LOC120094217 Neighboring gene family with sequence similarity 162, member A, pseudogene 1 Neighboring gene quinolinate phosphoribosyltransferase, pseudogene 1 Neighboring gene ribosomal protein S20 like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein. Liu W, et al. Nat Immunol, 2001 Oct. PMID 11577348
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inhibitor of Bruton tyrosine kinase
    Names
    inhibitor of Bruton agammaglobulinemia tyrosine kinase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427757.1 → NP_001414686.1  inhibitor of Bruton tyrosine kinase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I1T2, D3ZH46
      Related
      ENSRNOP00000081930.2, ENSRNOT00000116914.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      95505630..95579435 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082545.2 → XP_038938473.1  inhibitor of Bruton tyrosine kinase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUJ7, D3ZH46
      Conserved Domains (7) summary
      COG5184
      Location:139 → 341
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      sd00045
      Location:51 → 82
      ANK; ANK repeat [structural motif]
      cd18301
      Location:546 → 651
      BTB1_POZ_IBtk; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
      cd18302
      Location:763 → 875
      BTB2_POZ_IBtk; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
      cd18500
      Location:871 → 930
      BACK_IBtk; BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
      pfam00415
      Location:247 → 299
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam12796
      Location:45 → 116
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_039082547.2 → XP_038938475.1  inhibitor of Bruton tyrosine kinase isoform X4

      Conserved Domains (3) summary
      cd18301
      Location:1 → 92
      BTB1_POZ_IBtk; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
      cd18302
      Location:204 → 316
      BTB2_POZ_IBtk; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
      cd18500
      Location:312 → 371
      BACK_IBtk; BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk)

    3. XM_063265559.1 → XP_063121629.1  inhibitor of Bruton tyrosine kinase isoform X3

      UniProtKB/TrEMBL
      A6I1T3

    4. XM_039082546.2 → XP_038938474.1  inhibitor of Bruton tyrosine kinase isoform X2

      UniProtKB/TrEMBL
      A6I1T3
      Conserved Domains (6) summary
      COG5184
      Location:139 → 341
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      sd00045
      Location:51 → 82
      ANK; ANK repeat [structural motif]
      cd18301
      Location:547 → 652
      BTB1_POZ_IBtk; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
      cd18302
      Location:764 → 870
      BTB2_POZ_IBtk; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
      pfam00415
      Location:247 → 299
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam12796
      Location:45 → 116
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version

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