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    Tmem196 transmembrane protein 196 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500750, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem196provided by RGD
    Official Full Name
    transmembrane protein 196provided by RGD
    Primary source
    RGD:1562527
    See related
    EnsemblRapid:ENSRNOG00000037435 AllianceGenome:RGD:1562527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562527
    Summary
    Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of cell growth; and negative regulation of cell migration. Predicted to be located in cytoplasm. Orthologous to human TMEM196 (transmembrane protein 196). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 140.9), Brain (RPKM 59.1) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem196 in Genome Data Viewer
    Location:
    6q33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (147039315..147102464)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (140895556..140959501)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (147874536..147940231)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene heat shock protein 90 alpha family class A member 1, pseudogene 4 Neighboring gene U6 spliceosomal RNA Neighboring gene protein yippee-like 5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TMEM196 acts as a novel functional tumour suppressor inactivated by DNA methylation and is a potential prognostic biomarker in lung cancer. Liu WB, et al. Oncotarget, 2015 Aug 28. PMID 26056045, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM196 acts as a novel functional tumour suppressor inactivated by DNA methylation and is an independent prognostic factor of lung cancer
      Title: TMEM196 acts as a novel functional tumour suppressor inactivated by DNA methylation and is a potential prognostic biomarker in lung cancer.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC109451

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 196

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044269.3 → NP_001037734.1  transmembrane protein 196 isoform 2

      See identical proteins and their annotated locations for NP_001037734.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q5EB63

    2. NM_001399754.2 → NP_001386683.1  transmembrane protein 196 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    3. NM_001414975.1 → NP_001401904.1  transmembrane protein 196 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      Related
      ENSRNOP00000107128.1, ENSRNOT00000161658.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      147039315..147102464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240702.5 → XP_006240764.1  transmembrane protein 196 isoform X3

      UniProtKB/TrEMBL
      A0A8L2QSV5
      Related
      ENSRNOP00000053487.2, ENSRNOT00000056649.4

    2. XM_017594310.3 → XP_017449799.1  transmembrane protein 196 isoform X1

    3. XM_017594311.3 → XP_017449800.1  transmembrane protein 196 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5EB63.1 GenPept UniProtKB/Swiss-Prot:Q5EB63

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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