Kbtbd6 kelch repeat and BTB domain containing 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kbtbd6provided by RGD
Official Full Name: kelch repeat and BTB domain containing 6provided by RGD
Primary source: RGD:1305086
See related: AllianceGenome:RGD:1305086
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; and regulation of Rac protein signal transduction. Predicted to be located in nucleus. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to several human genes including KBTBD6 (kelch repeat and BTB domain containing 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 15q12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (61257360..61259117)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (54848285..54850042)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (61731574..61733331)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rac protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Rac protein signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kelch repeat and BTB domain-containing protein 6

Names: kelch repeat and BTB (POZ) domain containing 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012045.2 → NP_001012045.2 kelch repeat and BTB domain-containing protein 6

See identical proteins and their annotated locations for NP_001012045.2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A6HTZ3, M0R4Q5, Q5U218

Conserved Domains (4) summary

smart00225
Location:64 → 168

BTB; Broad-Complex, Tramtrack and Bric a brac

smart00875
Location:173 → 280

BACK; BTB And C-terminal Kelch

pfam00651
Location:53 → 164

BTB; BTB/POZ domain

pfam01344
Location:444 → 482

Kelch_1; Kelch motif