U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Rdx radixin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315655, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rdxprovided by RGD
    Official Full Name
    radixinprovided by RGD
    Primary source
    RGD:1359472
    See related
    EnsemblRapid:ENSRNOG00000012237 AllianceGenome:RGD:1359472
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables actin binding activity and protein kinase A binding activity. Involved in several processes, including apical protein localization; barbed-end actin filament capping; and cellular response to platelet-derived growth factor stimulus. Located in several cellular components, including T-tubule; cleavage furrow; and midbody. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 24. Orthologous to human RDX (radixin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 695.8), Lung (RPKM 608.4) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rdx in Genome Data Viewer
    Location:
    8q24
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (61275792..61348260)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (52379494..52437673)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (56570728..56612851)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ferredoxin 1 Neighboring gene mitochondrial ribosomal protein L1, pseudogene 1 Neighboring gene ribosomal protein S19, pseudogene 12 Neighboring gene microRNA 6329 Neighboring gene zinc finger CCCH type containing 12C Neighboring gene uncharacterized LOC120094154 Neighboring gene uncharacterized LOC134479974

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC95168

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding  
    enables actin binding  
    enables actin binding PubMed 
    enables actin binding  
    enables cell adhesion molecule binding  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein kinase A binding PubMed 
    Items 1 - 25 of 34
    Process Evidence Code Pubs
    involved_in apical protein localization PubMed 
    acts_upstream_of_or_within apical protein localization  
    involved_in barbed-end actin filament capping PubMed 
    involved_in cellular response to platelet-derived growth factor stimulus PubMed 
    involved_in cellular response to thyroid hormone stimulus PubMed 
    involved_in cellular response to thyroid hormone stimulus  
    involved_in establishment of endothelial barrier  
    involved_in establishment of protein localization  
    involved_in establishment of protein localization to plasma membrane PubMed 
    acts_upstream_of_or_within microvillus assembly  
    involved_in negative regulation of GTPase activity  
    involved_in negative regulation of adherens junction organization  
    involved_in negative regulation of cell size  
    involved_in negative regulation of homotypic cell-cell adhesion  
    involved_in positive regulation of G1/S transition of mitotic cell cycle PubMed 
    involved_in positive regulation of G1/S transition of mitotic cell cycle  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of early endosome to late endosome transport  
    involved_in positive regulation of early endosome to late endosome transport  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of protein catabolic process  
    involved_in positive regulation of protein localization to early endosome  
    involved_in positive regulation of protein localization to early endosome  
    involved_in protein kinase A signaling PubMed 
    involved_in protein localization to plasma membrane  
    involved_in regulation of Rap protein signal transduction PubMed 
    involved_in regulation of actin filament bundle assembly  
    involved_in regulation of cell shape  
    involved_in regulation of cell shape  
    involved_in regulation of cell size  
    involved_in regulation of organelle assembly  
    involved_in regulation of organelle assembly  
    involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping  
    involved_in regulation of ruffle assembly  
    Items 1 - 25 of 34
    Items 1 - 20 of 27
    Component Evidence Code Pubs
    located_in T-tubule PubMed 
    is_active_in adherens junction  
    located_in adherens junction PubMed 
    is_active_in apical part of cell  
    located_in apical part of cell  
    located_in apical plasma membrane  
    located_in cell periphery  
    located_in cell tip PubMed 
    located_in cleavage furrow PubMed 
    located_in cortical actin cytoskeleton PubMed 
    located_in cortical actin cytoskeleton  
    is_active_in filopodium  
    located_in filopodium PubMed 
    located_in filopodium  
    located_in focal adhesion  
    located_in lamellipodium PubMed 
    located_in lamellipodium  
    is_active_in microvillus  
    located_in microvillus PubMed 
    located_in microvillus  
    located_in midbody PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in ruffle  
    located_in stereocilium  
    located_in stereocilium base  
    Items 1 - 20 of 27

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005889.3NP_001005889.2  radixin isoform 2

      See identical proteins and their annotated locations for NP_001005889.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5Y0V6, Q5PQK5, Q5WQV5
      Related
      ENSRNOP00000071354.3, ENSRNOT00000085316.3
      Conserved Domains (5) summary
      smart00295
      Location:7206
      B41; Band 4.1 homologues
      cd13194
      Location:200296
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00373
      Location:91206
      FERM_M; FERM central domain
      pfam00769
      Location:347583
      ERM; Ezrin/radixin/moesin family
      pfam09379
      Location:971
      FERM_N; FERM N-terminal domain
    2. NM_001433753.1NP_001420682.1  radixin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      E9PT65, Q5WQV5
    3. NM_001433754.1NP_001420683.1  radixin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      E9PT65, Q5WQV5
    4. NM_001433755.1NP_001420684.1  radixin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      E9PT65, Q5WQV5
    5. NM_001433756.1NP_001420685.1  radixin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      E9PT65, Q5WQV5
    6. NM_001433757.1NP_001420686.1  radixin isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5Y0V6, Q5PQK5, Q5WQV5
    7. NM_001433758.1NP_001420687.1  radixin isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      T1SRT4
    8. NM_001433759.1NP_001420688.1  radixin isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      T1SRT4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      61275792..61348260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265453.1XP_063121523.1  radixin isoform X1

    2. XM_039081453.2XP_038937381.1  radixin isoform X1

      Conserved Domains (3) summary
      smart00295
      Location:7206
      B41; Band 4.1 homologues
      cd13194
      Location:200296
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347583
      ERM; Ezrin/radixin/moesin family
    3. XM_063265455.1XP_063121525.1  radixin isoform X2

      UniProtKB/TrEMBL
      Q5WQV5
    4. XM_063265456.1XP_063121526.1  radixin isoform X2

      UniProtKB/TrEMBL
      Q5WQV5
    5. XM_039081455.2XP_038937383.1  radixin isoform X2

      UniProtKB/TrEMBL
      Q5WQV5
      Related
      ENSRNOP00000035840.6, ENSRNOT00000034924.7
      Conserved Domains (3) summary
      smart00295
      Location:7206
      B41; Band 4.1 homologues
      cd13194
      Location:200296
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347582
      ERM; Ezrin/radixin/moesin family
    6. XM_039081456.2XP_038937384.1  radixin isoform X3

      Related
      ENSRNOP00000108148.1, ENSRNOT00000157352.1
      Conserved Domains (2) summary
      smart00295
      Location:7206
      B41; Band 4.1 homologues
      cd13194
      Location:200296
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    7. XM_063265459.1XP_063121529.1  radixin isoform X3

    8. XM_063265454.1XP_063121524.1  radixin isoform X1

    9. XM_039081452.2XP_038937380.1  radixin isoform X1

      UniProtKB/TrEMBL
      E9PT65, Q5WQV5
      Related
      ENSRNOP00000077207.2, ENSRNOT00000117679.2
      Conserved Domains (3) summary
      smart00295
      Location:7206
      B41; Band 4.1 homologues
      cd13194
      Location:200296
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00769
      Location:347583
      ERM; Ezrin/radixin/moesin family

    RNA

    1. XR_010053960.1 RNA Sequence

    2. XR_010053962.1 RNA Sequence

    3. XR_005487816.2 RNA Sequence

    4. XR_010053961.1 RNA Sequence

    External link. Please review our privacy policy.