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    Klk10 kallikrein related-peptidase 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292850, updated on 9-Dec-2024

    Summary

    Official Symbol
    Klk10provided by RGD
    Official Full Name
    kallikrein related-peptidase 10provided by RGD
    Primary source
    RGD:1303242
    See related
    EnsemblRapid:ENSRNOG00000030281 AllianceGenome:RGD:1303242
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Klnj
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in regulation of systemic arterial blood pressure and zymogen activation. Predicted to be active in extracellular space and secretory granule. Human ortholog(s) of this gene implicated in artery disease (multiple); cardiomyopathy; chronic kidney disease (multiple); and prostate cancer. Orthologous to several human genes including KLK1 (kallikrein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 7.4), Testes (RPKM 5.1) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Klk10 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (103371638..103375918)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (94234536..94239369)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (99718275..99722743)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene kallikrein related-peptidase 12 Neighboring gene kallikrein related-peptidase 11 Neighboring gene kallikrein related-peptidase 9 Neighboring gene kallikrein related-peptidase 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity  
    enables serine-type endopeptidase activity  
    Process Evidence Code Pubs
    involved_in biological_process  
    involved_in proteolysis  
    involved_in regulation of systemic arterial blood pressure  
    involved_in zymogen activation  
    Component Evidence Code Pubs
    is_active_in extracellular space  
    is_active_in secretory granule  

    General protein information

    Preferred Names
    kallikrein-10
    Names
    kallikrein j
    NP_001004100.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004100.2 → NP_001004100.1  kallikrein-10 precursor

      See identical proteins and their annotated locations for NP_001004100.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5Y0L8, Q6IE55
      Related
      ENSRNOP00000043107.2, ENSRNOT00000048240.4
      Conserved Domains (1) summary
      smart00020
      Location:50 → 272
      Tryp_SPc; Trypsin-like serine protease

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      103371638..103375918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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