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    Tnfrsf17 TNF receptor superfamily member 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287034, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tnfrsf17provided by RGD
    Official Full Name
    TNF receptor superfamily member 17provided by RGD
    Primary source
    RGD:1304703
    See related
    AllianceGenome:RGD:1304703
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in tumor necrosis factor-mediated signaling pathway. Predicted to act upstream of or within lymphocyte homeostasis. Human ortholog(s) of this gene implicated in colon carcinoma and multiple myeloma. Orthologous to human TNFRSF17 (TNF receptor superfamily member 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 27.3), Thymus (RPKM 20.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tnfrsf17 in Genome Data Viewer
    Location:
    10q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (4808023..4813857, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (4301023..4306889, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (4252097..4258335, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095243 Neighboring gene sorting nexin 29 Neighboring gene uncharacterized LOC134480744 Neighboring gene uncharacterized LOC120095016 Neighboring gene G1 to S phase transition 1 Neighboring gene uncharacterized LOC100911627

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth. Rennert P, et al. J Exp Med, 2000 Dec 4. PMID 11104810, Free PMC Article
    2. Graft-versus-tumor response in patients with multiple myeloma is associated with antibody response to BCMA, a plasma-cell membrane receptor. Bellucci R, et al. Blood, 2005 May 15. PMID 15692072, Free PMC Article
    3. BCMA is essential for the survival of long-lived bone marrow plasma cells. O'Connor BP, et al. J Exp Med, 2004 Jan 5. PMID 14707116, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within lymphocyte homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 17
    Names
    tumor necrosis factor receptor superfamily, member 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105761.1 → NP_001099231.1  tumor necrosis factor receptor superfamily member 17

      See identical proteins and their annotated locations for NP_001099231.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474017
      UniProtKB/TrEMBL
      A6K4H4, D3ZKQ8
      Conserved Domains (1) summary
      cd13414
      Location:1 → 165
      TNFRSF17; Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA), as well as TNFRSF13A

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      4808023..4813857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597054.3 → XP_017452543.1  tumor necrosis factor receptor superfamily member 17 isoform X1

      UniProtKB/TrEMBL
      A6K4H4, D3ZKQ8
      Conserved Domains (1) summary
      cd13414
      Location:1 → 165
      TNFRSF17; Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA), as well as TNFRSF13A
    Nucleotide Protein Strain
    Heading Accession and Version

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