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    Islr2 immunoglobulin superfamily containing leucine-rich repeat 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100910729, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Islr2provided by RGD
    Official Full Name
    immunoglobulin superfamily containing leucine-rich repeat 2provided by RGD
    Primary source
    RGD:6497037
    See related
    EnsemblRapid:ENSRNOG00000050714 AllianceGenome:RGD:6497037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in positive regulation of axon extension. Predicted to be located in membrane. Predicted to be active in cell surface. Orthologous to human ISLR2 (immunoglobulin superfamily containing leucine rich repeat 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 20.6), Testes (RPKM 5.2) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Islr2 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (67504042..67512125, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (58608165..58616246, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (62983333..62991401, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094173 Neighboring gene signaling receptor and transporter of retinol STRA6 Neighboring gene immunoglobulin superfamily containing leucine-rich repeat Neighboring gene uncharacterized LOC134480059 Neighboring gene PML nuclear body scaffold

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Mandai K, et al. Neuron, 2009 Sep 10. PMID 19755105, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of axon extension IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    immunoglobulin superfamily containing leucine-rich repeat protein 2
    Names
    immunoglobulin superfamily containing leucine-rich repeat protein 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399427.1 → NP_001386356.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6J4Z5, M0R4G0
      Related
      ENSRNOP00000100631.1, ENSRNOT00000164549.1
      Conserved Domains (5) summary
      TIGR00864
      Location:155 → 229
      PCC; polycystin cation channel protein
      sd00033
      Location:37 → 53
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:100 → 160
      LRR_8; Leucine rich repeat
      cd00096
      Location:257 → 264
      Ig; Ig strand B [structural motif]
      cl11960
      Location:249 → 374
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      67504042..67512125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082410.2 → XP_038938338.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      UniProtKB/TrEMBL
      A6J4Z5, M0R4G0
      Conserved Domains (5) summary
      TIGR00864
      Location:155 → 229
      PCC; polycystin cation channel protein
      sd00033
      Location:37 → 53
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:100 → 160
      LRR_8; Leucine rich repeat
      cd00096
      Location:257 → 264
      Ig; Ig strand B [structural motif]
      cl11960
      Location:249 → 374
      Ig; Immunoglobulin domain

    2. XM_008766373.4 → XP_008764595.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008764595.1

      UniProtKB/TrEMBL
      A6J4Z5, M0R4G0
      Conserved Domains (5) summary
      TIGR00864
      Location:155 → 229
      PCC; polycystin cation channel protein
      sd00033
      Location:37 → 53
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:100 → 160
      LRR_8; Leucine rich repeat
      cd00096
      Location:257 → 264
      Ig; Ig strand B [structural motif]
      cl11960
      Location:249 → 374
      Ig; Immunoglobulin domain

    3. XM_063264716.1 → XP_063120786.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      UniProtKB/TrEMBL
      A6J4Z5, M0R4G0
      Related
      ENSRNOP00000099630.1, ENSRNOT00000128216.1

    4. XM_039082409.2 → XP_038938337.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      UniProtKB/TrEMBL
      A6J4Z5, M0R4G0
      Conserved Domains (5) summary
      TIGR00864
      Location:155 → 229
      PCC; polycystin cation channel protein
      sd00033
      Location:37 → 53
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:100 → 160
      LRR_8; Leucine rich repeat
      cd00096
      Location:257 → 264
      Ig; Ig strand B [structural motif]
      cl11960
      Location:249 → 374
      Ig; Immunoglobulin domain

    5. XM_039082404.2 → XP_038938332.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      UniProtKB/TrEMBL
      A6J4Z5, M0R4G0
      Conserved Domains (5) summary
      TIGR00864
      Location:155 → 229
      PCC; polycystin cation channel protein
      sd00033
      Location:37 → 53
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:100 → 160
      LRR_8; Leucine rich repeat
      cd00096
      Location:257 → 264
      Ig; Ig strand B [structural motif]
      cl11960
      Location:249 → 374
      Ig; Immunoglobulin domain

    6. XM_006243178.5 → XP_006243240.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006243240.1

      UniProtKB/TrEMBL
      A6J4Z5, M0R4G0
      Related
      ENSRNOP00000112570.1, ENSRNOT00000172539.1
      Conserved Domains (5) summary
      TIGR00864
      Location:155 → 229
      PCC; polycystin cation channel protein
      sd00033
      Location:37 → 53
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:100 → 160
      LRR_8; Leucine rich repeat
      cd00096
      Location:257 → 264
      Ig; Ig strand B [structural motif]
      cl11960
      Location:249 → 374
      Ig; Immunoglobulin domain

    7. XM_039082405.1 → XP_038938333.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      UniProtKB/TrEMBL
      A6J4Z5, M0R4G0
      Related
      ENSRNOP00000111974.1, ENSRNOT00000149205.1
      Conserved Domains (5) summary
      TIGR00864
      Location:155 → 229
      PCC; polycystin cation channel protein
      sd00033
      Location:37 → 53
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:100 → 160
      LRR_8; Leucine rich repeat
      cd00096
      Location:257 → 264
      Ig; Ig strand B [structural motif]
      cl11960
      Location:249 → 374
      Ig; Immunoglobulin domain

    8. XM_017596042.3 → XP_017451531.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      UniProtKB/TrEMBL
      A6J4Z5, M0R4G0
      Related
      ENSRNOP00000064244.2, ENSRNOT00000070885.4
      Conserved Domains (5) summary
      TIGR00864
      Location:155 → 229
      PCC; polycystin cation channel protein
      sd00033
      Location:37 → 53
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:100 → 160
      LRR_8; Leucine rich repeat
      cd00096
      Location:257 → 264
      Ig; Ig strand B [structural motif]
      cl11960
      Location:249 → 374
      Ig; Immunoglobulin domain

    9. XM_039082403.2 → XP_038938331.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      UniProtKB/TrEMBL
      A6J4Z5, M0R4G0
      Conserved Domains (5) summary
      TIGR00864
      Location:155 → 229
      PCC; polycystin cation channel protein
      sd00033
      Location:37 → 53
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:100 → 160
      LRR_8; Leucine rich repeat
      cd00096
      Location:257 → 264
      Ig; Ig strand B [structural motif]
      cl11960
      Location:249 → 374
      Ig; Immunoglobulin domain

    10. XM_039082408.2 → XP_038938336.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

      UniProtKB/TrEMBL
      A6J4Z5, M0R4G0
      Conserved Domains (5) summary
      TIGR00864
      Location:155 → 229
      PCC; polycystin cation channel protein
      sd00033
      Location:37 → 53
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:100 → 160
      LRR_8; Leucine rich repeat
      cd00096
      Location:257 → 264
      Ig; Ig strand B [structural motif]
      cl11960
      Location:249 → 374
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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