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    Mindy2 MINDY lysine 48 deubiquitinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363089, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mindy2provided by RGD
    Official Full Name
    MINDY lysine 48 deubiquitinase 2provided by RGD
    Primary source
    RGD:1311456
    See related
    EnsemblRapid:ENSRNOG00000061337 AllianceGenome:RGD:1311456
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam63b; RGD1311456
    Summary
    Predicted to enable peptidase activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in chromatin remodeling and proteolysis. Predicted to be located in nucleoplasm. Orthologous to human MINDY2 (MINDY lysine 48 deubiquitinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 185.7), Lung (RPKM 174.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mindy2 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (80149127..80210011, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (71268274..71327698, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (77029346..77089208, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene SAFB-like, transcription modulator Neighboring gene uncharacterized LOC102551907 Neighboring gene ADAM metallopeptidase domain 10 Neighboring gene uncharacterized LOC120094202 Neighboring gene lipase C, hepatic type

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process  
    involved_in chromatin remodeling  
    involved_in proteolysis  
    Component Evidence Code Pubs
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    MINDY lysine 48 deubiquitinase 2; ubiquitin carboxyl-terminal hydrolase MINDY-2
    Names
    family with sequence similarity 63, member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429419.1NP_001416348.1  MINDY lysine 48 deubiquitinase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6KES4, D3ZWA1
    2. NM_001429420.1NP_001416349.1  MINDY lysine 48 deubiquitinase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZV90, A0A8I5ZZG8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      80149127..80210011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_343420.11XP_343421.3  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X1

      Related
      ENSRNOP00000070456.1, ENSRNOT00000078685.3
      Conserved Domains (1) summary
      pfam04424
      Location:255366
      DUF544; Protein of unknown function (DUF544)
    2. XM_017596087.3XP_017451576.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X2

      Related
      ENSRNOP00000083544.1, ENSRNOT00000094906.2
    3. XM_039082503.2XP_038938431.1  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X3

      UniProtKB/TrEMBL
      A6KES6
      Conserved Domains (1) summary
      pfam04424
      Location:255366
      MINDY_DUB; MINDY deubiquitinase
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