H3c1 H3 clustered histone 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: H3c1provided by RGD
Full Name: H3 clustered histone 1provided by RGD
Primary source: RGD:1598076
See related: EnsemblRapid:ENSRNOG00000074836 AllianceGenome:RGD:1598076
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hist1h3a
Summary: Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be involved in epigenetic regulation of gene expression and nucleosome assembly. Predicted to act upstream of with a positive effect on gene expression. Predicted to be located in nucleoplasm. Predicted to be part of nucleosome. Orthologous to several human genes including H3C1 (H3 clustered histone 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 6567.4), Spleen (RPKM 4212.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 17p11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (41796236..41796759)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (41368379..41368902)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (43616206..43616735)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Hist1h2bc (e-PCR), detects polymorphism
- UniSTS:259084

RH131033 (e-PCR)
- UniSTS:214316

UniSTS:491901 (e-PCR)
- UniSTS:491901

UniSTS:488581 (e-PCR)
- UniSTS:488581

UniSTS:493012 (e-PCR)
- UniSTS:493012

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epigenetic regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect gene expression	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone cluster 3, H3

Names: histone H3.1; histone cluster 1 H3 family member A; histone cluster 1, H3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.