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    Vps33a VPS33A core subunit of CORVET and HOPS complexes [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65081, updated on 9-Dec-2024

    Summary

    Official Symbol
    Vps33aprovided by RGD
    Official Full Name
    VPS33A core subunit of CORVET and HOPS complexesprovided by RGD
    Primary source
    RGD:620643
    See related
    EnsemblRapid:ENSRNOG00000056889 AllianceGenome:RGD:620643
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    r-Vps33a
    Summary
    Predicted to be involved in several processes, including autophagosome maturation; melanosome localization; and regulation of lysosomal lumen pH. Predicted to act upstream of or within pigmentation; platelet formation; and regulation of developmental pigmentation. Predicted to be located in autophagosome; endosome; and perinuclear region of cytoplasm. Predicted to be part of several cellular components, including AP-3 adaptor complex; CORVET complex; and clathrin complex. Predicted to be active in lysosome. Orthologous to human VPS33A (VPS33A core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 79.2), Brain (RPKM 78.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Vps33a in Genome Data Viewer
    Location:
    12q16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (38685484..38710668)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (33024596..33051399)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (38459816..38482903)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene CAP-GLY domain containing linker protein 1 Neighboring gene uncharacterized LOC134481295 Neighboring gene uncharacterized LOC120095846 Neighboring gene diablo, IAP-binding mitochondrial protein Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 Neighboring gene leucine rich repeat containing 43

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in autophagosome maturation  
    involved_in autophagosome maturation  
    involved_in biological_process  
    involved_in endosome to lysosome transport  
    involved_in endosome to lysosome transport  
    involved_in intracellular protein transport  
    involved_in lysosome localization  
    involved_in lysosome localization  
    involved_in melanosome localization  
    involved_in melanosome localization  
    acts_upstream_of_or_within pigmentation  
    involved_in platelet formation  
    acts_upstream_of_or_within platelet formation  
    involved_in protein transport  
    involved_in regulation of developmental pigmentation  
    acts_upstream_of_or_within regulation of developmental pigmentation  
    involved_in regulation of lysosomal lumen pH  
    involved_in regulation of lysosomal lumen pH  
    involved_in regulation of lysosomal lumen pH  
    involved_in vesicle-mediated transport  
    involved_in vesicle-mediated transport  
    acts_upstream_of_or_within vesicle-mediated transport  
    Items 1 - 20 of 23
    Component Evidence Code Pubs
    part_of AP-3 adaptor complex  
    part_of AP-3 adaptor complex  
    part_of CORVET complex  
    part_of CORVET complex  
    part_of CORVET complex  
    part_of HOPS complex  
    part_of HOPS complex  
    located_in autophagosome  
    located_in autophagosome  
    located_in autophagosome  
    part_of clathrin complex  
    part_of clathrin complex  
    located_in clathrin-coated vesicle  
    located_in early endosome  
    located_in early endosome  
    located_in late endosome  
    located_in late endosome membrane  
    located_in lysosomal membrane  
    is_active_in lysosome  
    located_in lysosome  
    located_in lysosome  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    Items 1 - 20 of 23

    General protein information

    Preferred Names
    vacuolar protein sorting-associated protein 33A
    Names
    VPS33A CORVET/HOPS core subunit
    vacuolar protein sorting 33 homolog A
    vacuolar protein sorting 33A
    vacuolar protein sorting protein 33a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022961.3NP_075250.2  vacuolar protein sorting-associated protein 33A

      See identical proteins and their annotated locations for NP_075250.2

      Status: PROVISIONAL

      Source sequence(s)
      BC105752
      UniProtKB/Swiss-Prot
      Q63615
      UniProtKB/TrEMBL
      A0A0G2K5N1, A0A9K3Y802, Q3KRF0
      Related
      ENSRNOP00000073489.2, ENSRNOT00000090343.3
      Conserved Domains (1) summary
      pfam00995
      Location:34585
      Sec1; Sec1 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      38685484..38710668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089725.2XP_038945653.1  vacuolar protein sorting-associated protein 33A isoform X1

      Conserved Domains (1) summary
      pfam00995
      Location:34435
      Sec1; Sec1 family
    2. XM_039089726.2XP_038945654.1  vacuolar protein sorting-associated protein 33A isoform X2

      Conserved Domains (1) summary
      pfam00995
      Location:34317
      Sec1; Sec1 family
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