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    Galnt2 polypeptide N-acetylgalactosaminyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292090, updated on 9-Dec-2024

    Summary

    Official Symbol
    Galnt2provided by RGD
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 2provided by RGD
    Primary source
    RGD:1310692
    See related
    EnsemblRapid:ENSRNOG00000019143 AllianceGenome:RGD:1310692
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable manganese ion binding activity and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation and protein maturation. Predicted to be located in Golgi stack and perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human GALNT2 (polypeptide N-acetylgalactosaminyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 107.1), Heart (RPKM 89.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Galnt2 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (69110657..69222237)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (52213226..52324816)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (57043858..57115123)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483659 Neighboring gene cytochrome c oxidase subunit VIc, pseudogene Neighboring gene piggyBac transposable element derived 5 Neighboring gene uncharacterized LOC108348970

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in Golgi stack  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 2
    Names
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
    NP_001099666.2
    XP_038953585.1
    XP_038953586.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106196.2NP_001099666.2  polypeptide N-acetylgalactosaminyltransferase 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      B5DF50
      Related
      ENSRNOP00000062956.2, ENSRNOT00000065431.3
      Conserved Domains (2) summary
      cd02510
      Location:138433
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:445562
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      69110657..69222237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097658.2XP_038953586.1  polypeptide N-acetylgalactosaminyltransferase 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JU25
      Conserved Domains (2) summary
      cd02510
      Location:116411
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:423540
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    2. XM_039097657.1XP_038953585.1  polypeptide N-acetylgalactosaminyltransferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JU25
      Related
      ENSRNOP00000068936.1, ENSRNOT00000080860.3
      Conserved Domains (2) summary
      cd02510
      Location:119414
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:426543
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
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