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    Heatr5a HEAT repeat containing 5A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362737, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Heatr5aprovided by RGD
    Official Full Name
    HEAT repeat containing 5Aprovided by RGD
    Primary source
    RGD:1561116
    See related
    EnsemblRapid:ENSRNOG00000006483 AllianceGenome:RGD:1561116
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561116
    Summary
    Predicted to be involved in endocytosis; protein localization; and retrograde transport, endosome to Golgi. Predicted to be located in cytosol. Predicted to be active in endocytic vesicle. Orthologous to human HEATR5A (HEAT repeat containing 5A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 98.8), Lung (RPKM 87.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Heatr5a in Genome Data Viewer
    Location:
    6q23
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (75057226..75155207, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (69321869..69419861, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (72648654..72750202, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103536 Neighboring gene HECT domain E3 ubiquitin protein ligase 1 Neighboring gene uncharacterized LOC134479181 Neighboring gene uncharacterized LOC134479124 Neighboring gene G protein-coupled receptor 33, pseudogene 1 Neighboring gene D-aminoacyl-tRNA deacylase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    HEAT repeat-containing protein 5A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419842.1 → NP_001406771.1  HEAT repeat-containing protein 5A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AF96

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      75057226..75155207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262110.1 → XP_063118180.1  HEAT repeat-containing protein 5A isoform X8

      UniProtKB/TrEMBL
      A0A8I6AF96

    2. XM_063262109.1 → XP_063118179.1  HEAT repeat-containing protein 5A isoform X6

      UniProtKB/TrEMBL
      A0A8I6AF96

    3. XM_063262108.1 → XP_063118178.1  HEAT repeat-containing protein 5A isoform X7

      UniProtKB/TrEMBL
      A0A8I6AF96

    4. XM_039078140.1 → XP_038934068.1  HEAT repeat-containing protein 5A isoform X1

      UniProtKB/TrEMBL
      A0A8I6AF96
      Conserved Domains (1) summary
      sd00044
      Location:97 → 121
      HEAT; HEAT repeat [structural motif]

    5. XM_039078149.2 → XP_038934077.1  HEAT repeat-containing protein 5A isoform X6

      UniProtKB/TrEMBL
      A0A8I6AF96
      Related
      ENSRNOP00000091464.1, ENSRNOT00000119095.2
      Conserved Domains (1) summary
      sd00044
      Location:97 → 121
      HEAT; HEAT repeat [structural motif]

    6. XM_039078146.2 → XP_038934074.1  HEAT repeat-containing protein 5A isoform X4

      UniProtKB/TrEMBL
      A0A8I6AF96
      Conserved Domains (1) summary
      sd00044
      Location:97 → 121
      HEAT; HEAT repeat [structural motif]

    7. XM_039078144.2 → XP_038934072.1  HEAT repeat-containing protein 5A isoform X2

      UniProtKB/TrEMBL
      A0A8I6AF96
      Related
      ENSRNOP00000101861.1, ENSRNOT00000134452.1
      Conserved Domains (1) summary
      sd00044
      Location:97 → 121
      HEAT; HEAT repeat [structural motif]

    8. XM_039078147.2 → XP_038934075.1  HEAT repeat-containing protein 5A isoform X5

      UniProtKB/TrEMBL
      A0A8I6AF96
      Related
      ENSRNOP00000035775.5, ENSRNOT00000035309.6
      Conserved Domains (1) summary
      sd00044
      Location:97 → 121
      HEAT; HEAT repeat [structural motif]

    9. XM_039078145.2 → XP_038934073.1  HEAT repeat-containing protein 5A isoform X3

      UniProtKB/TrEMBL
      A0A8I6AF96
      Conserved Domains (1) summary
      sd00044
      Location:97 → 121
      HEAT; HEAT repeat [structural motif]

    10. XM_039078139.2 → XP_038934067.1  HEAT repeat-containing protein 5A isoform X1

      UniProtKB/TrEMBL
      A0A8I6AF96
      Conserved Domains (1) summary
      sd00044
      Location:97 → 121
      HEAT; HEAT repeat [structural motif]

    11. XM_039078141.2 → XP_038934069.1  HEAT repeat-containing protein 5A isoform X1

      UniProtKB/TrEMBL
      A0A8I6AF96
      Conserved Domains (1) summary
      sd00044
      Location:97 → 121
      HEAT; HEAT repeat [structural motif]

    12. XM_039078142.2 → XP_038934070.1  HEAT repeat-containing protein 5A isoform X1

      UniProtKB/TrEMBL
      A0A8I6AF96
      Conserved Domains (1) summary
      sd00044
      Location:97 → 121
      HEAT; HEAT repeat [structural motif]

    13. XM_039078143.2 → XP_038934071.1  HEAT repeat-containing protein 5A isoform X1

      UniProtKB/TrEMBL
      A0A8I6AF96
      Conserved Domains (1) summary
      sd00044
      Location:97 → 121
      HEAT; HEAT repeat [structural motif]

    14. XM_063262111.1 → XP_063118181.1  HEAT repeat-containing protein 5A isoform X9

      UniProtKB/TrEMBL
      A0A8I6AF96

    15. XM_039078151.2 → XP_038934079.1  HEAT repeat-containing protein 5A isoform X10

      UniProtKB/TrEMBL
      A0A8I6AF96
      Conserved Domains (1) summary
      sd00044
      Location:97 → 121
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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