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    Pask PAS domain containing serine/threonine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301617, updated on 9-Dec-2024

    Summary

    Official Symbol
    Paskprovided by RGD
    Official Full Name
    PAS domain containing serine/threonine kinaseprovided by RGD
    Primary source
    RGD:1306146
    See related
    EnsemblRapid:ENSRNOG00000016888 AllianceGenome:RGD:1306146
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation of glycogen biosynthetic process; protein autophosphorylation; and regulation of glucagon secretion. Predicted to be active in cytosol and nucleus. Orthologous to human PASK (PAS domain containing serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 82.4), Thymus (RPKM 45.7) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Pask in Genome Data Viewer
    Location:
    9q36
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (101291673..101333288, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (93844275..93886036, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (100450595..100479719, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-associated domain-containing protein 1 pseudogene Neighboring gene mitochondrial transcription termination factor 4 Neighboring gene protein NYNRIN-like Neighboring gene protein phosphatase 1, regulatory subunit 7 Neighboring gene U6 spliceosomal RNA Neighboring gene anoctamin 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Clone Names

    • MGC93882

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables phosphatidylinositol binding  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    PAS domain-containing serine/threonine-protein kinase
    NP_001009362.1
    XP_038939347.1
    XP_038939348.1
    XP_038939350.1
    XP_063123111.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009362.2NP_001009362.1  PAS domain-containing serine/threonine-protein kinase isoform 1

      See identical proteins and their annotated locations for NP_001009362.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      F7F091, Q5PQT0
      Related
      ENSRNOP00000022748.3, ENSRNOT00000022748.8
      Conserved Domains (3) summary
      cd00130
      Location:129228
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      cd14004
      Location:10611314
      STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
      pfam13426
      Location:343386
      PAS_9; PAS domain
    2. NM_001432217.1NP_001419146.1  PAS domain-containing serine/threonine-protein kinase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      F7F091, Q5PQT0
    3. NM_001432218.1NP_001419147.1  PAS domain-containing serine/threonine-protein kinase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      F7F091, Q5PQT0
    4. NM_001432219.1NP_001419148.1  PAS domain-containing serine/threonine-protein kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6GFT4
    5. NM_001432220.1NP_001419149.1  PAS domain-containing serine/threonine-protein kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6GFT4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      101291673..101333288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083420.2XP_038939348.1  PAS domain-containing serine/threonine-protein kinase isoform X1

      UniProtKB/TrEMBL
      F7F091, Q5PQT0
      Conserved Domains (3) summary
      cd00130
      Location:129228
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      cd14004
      Location:10611314
      STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
      pfam13426
      Location:343386
      PAS_9; PAS domain
    2. XM_039083422.2XP_038939350.1  PAS domain-containing serine/threonine-protein kinase isoform X2

      Conserved Domains (2) summary
      smart00091
      Location:129177
      PAS; PAS domain
      cd14004
      Location:10141267
      STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
    3. XM_039083419.2XP_038939347.1  PAS domain-containing serine/threonine-protein kinase isoform X1

      Conserved Domains (3) summary
      cd00130
      Location:129228
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      cd14004
      Location:10611314
      STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
      pfam13426
      Location:343386
      PAS_9; PAS domain
    4. XM_063267041.1XP_063123111.1  PAS domain-containing serine/threonine-protein kinase isoform X2

      Related
      ENSRNOP00000087231.1, ENSRNOT00000095651.2
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