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    Mef2a myocyte enhancer factor 2a [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309957, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mef2aprovided by RGD
    Official Full Name
    myocyte enhancer factor 2aprovided by RGD
    Primary source
    RGD:1359360
    See related
    EnsemblRapid:ENSRNOG00000047756 AllianceGenome:RGD:1359360
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including cellular response to calcium ion; cellular response to glucose stimulus; and dendrite morphogenesis. Located in nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human MEF2A (myocyte enhancer factor 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 399.7), Lung (RPKM 276.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mef2a in Genome Data Viewer
    Location:
    1q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (130258083..130392819, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (120847874..120982488, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (128207715..128341681, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483669 Neighboring gene LysM domain containing 4 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene uncharacterized LOC103691157

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 38
    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor binding  
    enables DNA-binding transcription factor binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables SMAD binding  
    enables SMAD binding  
    enables SMAD binding  
    enables chromatin binding  
    enables chromatin binding  
    enables chromatin binding  
    enables histone acetyltransferase binding  
    enables histone acetyltransferase binding  
    enables histone acetyltransferase binding  
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables protein dimerization activity  
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein kinase binding  
    enables protein kinase binding  
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding  
    Items 1 - 25 of 38
    Items 1 - 25 of 43
    Process Evidence Code Pubs
    involved_in DNA-templated transcription  
    involved_in DNA-templated transcription  
    involved_in ERK5 cascade  
    involved_in ERK5 cascade  
    involved_in ERK5 cascade  
    involved_in MAPK cascade  
    involved_in MAPK cascade  
    involved_in apoptotic process  
    involved_in cardiac conduction  
    involved_in cardiac conduction  
    involved_in cell differentiation  
    involved_in cell differentiation  
    involved_in cellular response to calcium ion PubMed 
    involved_in cellular response to calcium ion  
    involved_in cellular response to calcium ion  
    involved_in cellular response to glucose stimulus PubMed 
    involved_in dendrite morphogenesis PubMed 
    involved_in heart development  
    involved_in mitochondrial genome maintenance  
    involved_in mitochondrial genome maintenance  
    involved_in mitochondrion distribution  
    involved_in mitochondrion distribution  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in nervous system development  
    involved_in positive regulation of D-glucose import  
    acts_upstream_of_or_within positive regulation of D-glucose import  
    involved_in positive regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription  
    involved_in positive regulation of cardiac muscle hypertrophy  
    involved_in positive regulation of cardiac muscle hypertrophy  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of DNA-templated transcription  
    involved_in ventricular cardiac myofibril assembly  
    involved_in ventricular cardiac myofibril assembly  
    Items 1 - 25 of 43
    Component Evidence Code Pubs
    located_in chromatin  
    located_in chromatin  
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  
    located_in nucleus  
    part_of transcription regulator complex  
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    myocyte-specific enhancer factor 2A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014035.2NP_001014057.1  myocyte-specific enhancer factor 2A

      See identical proteins and their annotated locations for NP_001014057.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q2MJT0, Q66HD7
      Related
      ENSRNOP00000068690.3, ENSRNOT00000089723.3
      Conserved Domains (3) summary
      cd00265
      Location:278
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam11597
      Location:129238
      Med13_N; Mediator complex subunit 13 N-terminal
      pfam12347
      Location:98152
      HJURP_C; Holliday junction regulator protein family C-terminal repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      130258083..130392819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080825.2XP_038936753.1  myocyte-specific enhancer factor 2A isoform X1

      UniProtKB/Swiss-Prot
      Q2MJT0, Q66HD7
      UniProtKB/TrEMBL
      A0A0G2JSZ4, D8X2M2
      Related
      ENSRNOP00000064552.2, ENSRNOT00000072915.4
      Conserved Domains (3) summary
      cd00265
      Location:278
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam05109
      Location:129380
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam12347
      Location:97151
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
    2. XM_039080839.2XP_038936767.1  myocyte-specific enhancer factor 2A isoform X2

      UniProtKB/Swiss-Prot
      Q2MJT0, Q66HD7
      UniProtKB/TrEMBL
      A0A8I6AYJ3, A6JBR9
      Related
      ENSRNOP00000094055.1, ENSRNOT00000113672.2
      Conserved Domains (3) summary
      COG5068
      Location:1235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:278
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam05109
      Location:125378
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    3. XM_063265624.1XP_063121694.1  myocyte-specific enhancer factor 2A isoform X6

      UniProtKB/Swiss-Prot
      Q2MJT0, Q66HD7
    4. XM_039080833.2XP_038936761.1  myocyte-specific enhancer factor 2A isoform X1

      UniProtKB/Swiss-Prot
      Q2MJT0, Q66HD7
      UniProtKB/TrEMBL
      A0A0G2JSZ4, D8X2M2
      Conserved Domains (3) summary
      cd00265
      Location:278
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam05109
      Location:129380
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam12347
      Location:97151
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
    5. XM_063265619.1XP_063121689.1  myocyte-specific enhancer factor 2A isoform X5

      UniProtKB/Swiss-Prot
      Q2MJT0, Q66HD7
    6. XM_063265595.1XP_063121665.1  myocyte-specific enhancer factor 2A isoform X2

      UniProtKB/Swiss-Prot
      Q2MJT0, Q66HD7
      UniProtKB/TrEMBL
      A0A8I6AYJ3, A6JBR9
    7. XM_063265611.1XP_063121681.1  myocyte-specific enhancer factor 2A isoform X4

      UniProtKB/Swiss-Prot
      Q2MJT0, Q66HD7
    8. XM_063265617.1XP_063121687.1  myocyte-specific enhancer factor 2A isoform X3

      UniProtKB/Swiss-Prot
      Q2MJT0, Q66HD7
      UniProtKB/TrEMBL
      M0R6R7
      Related
      ENSRNOP00000065122.2, ENSRNOT00000070864.5
    9. XM_008759541.4XP_008757763.1  myocyte-specific enhancer factor 2A isoform X3

      UniProtKB/Swiss-Prot
      Q2MJT0, Q66HD7
      UniProtKB/TrEMBL
      M0R6R7
      Conserved Domains (3) summary
      COG5068
      Location:1235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:278
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam05109
      Location:125370
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    10. XM_039080830.2XP_038936758.1  myocyte-specific enhancer factor 2A isoform X1

      UniProtKB/Swiss-Prot
      Q2MJT0, Q66HD7
      UniProtKB/TrEMBL
      A0A0G2JSZ4, D8X2M2
      Conserved Domains (3) summary
      cd00265
      Location:278
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam05109
      Location:129380
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam12347
      Location:97151
      HJURP_C; Holliday junction regulator protein family C-terminal repeat
    11. XM_063265606.1XP_063121676.1  myocyte-specific enhancer factor 2A isoform X4

      UniProtKB/Swiss-Prot
      Q2MJT0, Q66HD7
    12. XM_039080843.2XP_038936771.1  myocyte-specific enhancer factor 2A isoform X3

      UniProtKB/Swiss-Prot
      Q2MJT0, Q66HD7
      UniProtKB/TrEMBL
      M0R6R7
      Conserved Domains (3) summary
      COG5068
      Location:1235
      ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]
      cd00265
      Location:278
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam05109
      Location:125370
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
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