Cd33 CD33 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd33provided by RGD
Official Full Name: CD33 moleculeprovided by RGD
Primary source: RGD:1596020
See related: EnsemblRapid:ENSRNOG00000037331 AllianceGenome:RGD:1596020
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein phosphatase binding activity; protein tyrosine phosphatase activator activity; and sialic acid binding activity. Predicted to be involved in several processes, including immune response-regulating signaling pathway; negative regulation of cytokine production; and negative regulation of monocyte activation. Predicted to be located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome. Predicted to be active in plasma membrane. Orthologous to several human genes including CD33 (CD33 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 39.3), Lung (RPKM 36.3) and 9 other tissues See more
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Genomic context

Location:: 1q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (103071985..103086687, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (93935418..93940452, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (98388811..98403539)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activator activity	ISO Inferred from Sequence Orthology more info
enables sialic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables sialic acid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Fc-gamma receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in immune response-inhibiting signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monocyte activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CD33 molecule; myeloid cell surface antigen CD33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432624.1 → NP_001419553.1 CD33 molecule isoform a precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6GJX8, A6JAI4
NM_001432625.1 → NP_001419554.1 CD33 molecule isoform a precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6GJX8, A6JAI4
NM_001432626.1 → NP_001419555.1 CD33 molecule isoform b precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

F1LTZ3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

103071985..103086687 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063280940.1 → XP_063137010.1 myeloid cell surface antigen CD33 isoform X1

Related

ENSRNOP00000050122.5, ENSRNOT00000047473.5
XM_017590101.3 → XP_017445590.1 myeloid cell surface antigen CD33 isoform X1

Conserved Domains (3) summary

smart00410
Location:26 → 119

IG_like; Immunoglobulin like

pfam13927
Location:144 → 215

Ig_3; Immunoglobulin domain

cl11960
Location:21 → 139

Ig; Immunoglobulin domain
XM_063280941.1 → XP_063137011.1 myeloid cell surface antigen CD33 isoform X2
XM_017590104.3 → XP_017445593.1 myeloid cell surface antigen CD33 isoform X3
XM_039100905.2 → XP_038956833.1 myeloid cell surface antigen CD33 isoform X4