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    Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691979, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Esco2provided by RGD
    Official Full Name
    establishment of sister chromatid cohesion N-acetyltransferase 2provided by RGD
    Primary source
    RGD:1593313
    See related
    EnsemblRapid:ENSRNOG00000015921 AllianceGenome:RGD:1593313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable lysine N-acetyltransferase activity, acting on acetyl phosphate as donor and peptide-lysine-N-acetyltransferase activity. Predicted to be involved in mitotic sister chromatid cohesion; post-translational protein acetylation; and regulation of DNA replication. Predicted to act upstream of or within several processes, including double-strand break repair; hematopoietic progenitor cell differentiation; and protein localization to chromatin. Predicted to be located in several cellular components, including Golgi apparatus; chromocenter; and chromosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Roberts syndrome and lung adenocarcinoma. Orthologous to human ESCO2 (establishment of sister chromatid cohesion N-acetyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 170.8), Spleen (RPKM 126.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Esco2 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (44210124..44230785, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (40034566..40052295, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (42500929..42519019, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene scavenger receptor class A, member 5 Neighboring gene uncharacterized LOC108352941 Neighboring gene uncharacterized LOC134482136 Neighboring gene PDZ binding kinase Neighboring gene coiled-coil domain containing 25 Neighboring gene NOP53 ribosome biogenesis factor, pseudogene 1 Neighboring gene uncharacterized LOC134482135

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Prenatal diagnosis of Roberts syndrome and detection of an ESCO2 frameshift mutation in a Pakistani family. Schulz S, et al. Prenat Diagn, 2008 Jan. PMID 18186147
    2. ESCO2 promotes lung adenocarcinoma progression by regulating hnRNPA1 acetylation. Zhu HE, et al. J Exp Clin Cancer Res, 2021 Feb 11. PMID 33573689, Free PMC Article
    3. The non-redundant function of cohesin acetyltransferase Esco2: some answers and new questions. Whelan G, et al. Nucleus, 2012 Jul 1. PMID 22614755
    4. Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion. Vega H, et al. Nat Genet, 2005 May. PMID 15821733
    5. Upregulation of KAT2B and ESCO2 gene expression level in patients with rheumatoid arthritis. Ghasemi A, et al. Clin Rheumatol, 2023 Jan. PMID 36104638

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-lysine-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-translational protein acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in XY body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromocenter ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in pericentric heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-acetyltransferase ESCO2
    XP_003751543.1
    XP_063130952.1
    XP_063130953.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433103.1 → NP_001420032.1  N-acetyltransferase ESCO2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6ADX3

    2. NM_001433107.1 → NP_001420036.1  N-acetyltransferase ESCO2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6ADX3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      44210124..44230785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274882.1 → XP_063130952.1  N-acetyltransferase ESCO2

      Related
      ENSRNOP00000068247.1, ENSRNOT00000076451.4

    2. XM_063274883.1 → XP_063130953.1  N-acetyltransferase ESCO2

      UniProtKB/TrEMBL
      A0A096MJS9, A0A8I6ADX3, A6K6K6

    3. XM_003751495.6 → XP_003751543.1  N-acetyltransferase ESCO2

      Conserved Domains (2) summary
      pfam13878
      Location:374 → 413
      zf-C2H2_3; zinc-finger of acetyl-transferase ESCO
      pfam13880
      Location:523 → 591
      Acetyltransf_13; ESCO1/2 acetyl-transferase
    Nucleotide Protein Strain
    Heading Accession and Version

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