Fto FTO, alpha-ketoglutarate dependent dioxygenase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ftoprovided by RGD
Official Full Name: FTO, alpha-ketoglutarate dependent dioxygenaseprovided by RGD
Primary source: RGD:1305121
See related: EnsemblRapid:ENSRNOG00000011728 AllianceGenome:RGD:1305121
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305121
Summary: Predicted to enable 2-oxoglutarate-dependent dioxygenase activity and ferrous iron binding activity. Involved in several processes, including negative regulation of eating behavior; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and response to bisphenol A. Predicted to be located in cytosol; nuclear speck; and plasma membrane. Used to study sciatic neuropathy. Biomarker of metabolic dysfunction-associated steatotic liver disease; obesity; transient cerebral ischemia; traumatic brain injury; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic neuropathy; nuclear senile cataract; renal cell carcinoma (multiple); and type 2 diabetes mellitus. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 136.3), Kidney (RPKM 111.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (31456749..31865011, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (15284898..15692142, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (16774549..17115098, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic Stroke Through Repressing m6A Modification of SIRT6.
Title: USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic Stroke Through Repressing m6A Modification of SIRT6.
N6 methyladenosine eraser FTO suppresses Staphylococcus aureus-induced ferroptosis of bone marrow mesenchymal stem cells to ameliorate osteomyelitis through regulating the MDM2/TLR4/SLC7A11 signaling pathway.
Title: N6 methyladenosine eraser FTO suppresses Staphylococcus aureus-induced ferroptosis of bone marrow mesenchymal stem cells to ameliorate osteomyelitis through regulating the MDM2/TLR4/SLC7A11 signaling pathway.
FTO overexpression expedites wound healing and alleviates depression in burn rats through facilitating keratinocyte migration and angiogenesis via mediating TFPI-2 demethylation.
Title: FTO overexpression expedites wound healing and alleviates depression in burn rats through facilitating keratinocyte migration and angiogenesis via mediating TFPI-2 demethylation.
Fat mass and obesity-associated protein (FTO) affects midpalatal suture bone remodeling during rapid maxillary expansion.
Title: Fat mass and obesity-associated protein (FTO) affects midpalatal suture bone remodeling during rapid maxillary expansion.
FTO-mediated m[6]A demethylation regulates GnRH expression in the hypothalamus via the PLCbeta3/Ca[2+]/CAMK signalling pathway.
Title: FTO-mediated m(6)A demethylation regulates GnRH expression in the hypothalamus via the PLCβ3/Ca(2+)/CAMK signalling pathway.
N6-methyladenosine demethylase FTO regulates synaptic and cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal rats.
Title: N6-methyladenosine demethylase FTO regulates synaptic and cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal rats.
N6-methyladenosine demethylase FTO related to hyperandrogenism in PCOS via AKT pathway.
Title: N6-methyladenosine demethylase FTO related to hyperandrogenism in PCOS via AKT pathway.
Downregulation of FTO in the hippocampus is associated with mental disorders induced by fear stress during pregnancy.
Title: Downregulation of FTO in the hippocampus is associated with mental disorders induced by fear stress during pregnancy.
Downregulated FTO Promotes MicroRNA-155-mediated Inflammatory Response in Cerebral Ischemia/Reperfusion Injury.
Title: Downregulated FTO Promotes MicroRNA-155-mediated Inflammatory Response in Cerebral Ischemia/Reperfusion Injury.
FTO represses NLRP3-mediated pyroptosis and alleviates myocardial ischemia-reperfusion injury via inhibiting CBL-mediated ubiquitination and degradation of beta-catenin.
Title: FTO represses NLRP3-mediated pyroptosis and alleviates myocardial ischemia-reperfusion injury via inhibiting CBL-mediated ubiquitination and degradation of β-catenin.

Submit: New GeneRIF Correction See all GeneRIFs (26)

General gene information

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Markers

BI295974 (e-PCR)
- UniSTS:246792

D19Mit4 (e-PCR), detects polymorphism
- UniSTS:119347

RH129525 (e-PCR)
- UniSTS:212827

BF396845 (e-PCR)
- UniSTS:245872

D19Got6 (e-PCR)
- UniSTS:113536

BE120169 (e-PCR)
- UniSTS:247256

RH134051 (e-PCR)
- UniSTS:217333

BE110336 (e-PCR)
- UniSTS:245244

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2-oxoglutarate-dependent dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables broad specificity oxidative DNA demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables broad specificity oxidative DNA demethylase activity	IEA Inferred from Electronic Annotation more info
enables broad specificity oxidative DNA demethylase activity	ISO Inferred from Sequence Orthology more info
enables broad specificity oxidative DNA demethylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ferrous iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferrous iron binding	IEA Inferred from Electronic Annotation more info
enables ferrous iron binding	ISO Inferred from Sequence Orthology more info
enables ferrous iron binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA N6-methyladenosine dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA N6-methyladenosine dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables mRNA N6-methyladenosine dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables mRNA N6-methyladenosine dioxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular_function	ND No biological Data available more info
enables oxidative RNA demethylase activity	ISO Inferred from Sequence Orthology more info
enables oxidative RNA demethylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA demethylase activity	IEA Inferred from Electronic Annotation more info
enables tRNA demethylase activity	ISO Inferred from Sequence Orthology more info
enables tRNA demethylase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA alkylation repair	IEA Inferred from Electronic Annotation more info
involved_in DNA alkylation repair	ISO Inferred from Sequence Orthology more info
involved_in RNA repair	IEA Inferred from Electronic Annotation more info
involved_in RNA repair	ISO Inferred from Sequence Orthology more info
involved_in adipose tissue development	IEA Inferred from Electronic Annotation more info
involved_in adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mRNA destabilization	IEA Inferred from Electronic Annotation more info
involved_in mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of brown fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid storage	IEA Inferred from Electronic Annotation more info
involved_in regulation of lipid storage	ISO Inferred from Sequence Orthology more info
involved_in regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of respiratory system process	IEA Inferred from Electronic Annotation more info
involved_in regulation of respiratory system process	ISO Inferred from Sequence Orthology more info
involved_in regulation of white fat cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of white fat cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to bisphenol A	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in snRNA processing	IEA Inferred from Electronic Annotation more info
involved_in snRNA processing	ISO Inferred from Sequence Orthology more info
involved_in temperature homeostasis	IEA Inferred from Electronic Annotation more info
involved_in temperature homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-ketoglutarate-dependent dioxygenase FTO

Names: U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO; fat mass and obesity associated; fat mass and obesity-associated protein; m6A(m)-demethylase FTO; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; mRNA N(6)-methyladenosine demethylase FTO; protein fto; tRNA N1-methyl adenine demethylase FTO

NP_001034802.1

EC 1.14.11.53

XP_038953492.1

EC 1.14.11.53

XP_038953493.1

EC 1.14.11.53

XP_038953494.1

EC 1.14.11.53

XP_038953495.1

EC 1.14.11.53

XP_038953496.1

EC 1.14.11.53

XP_063133931.1

EC 1.14.11.53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039713.1 → NP_001034802.1 alpha-ketoglutarate-dependent dioxygenase FTO

See identical proteins and their annotated locations for NP_001034802.1

Status: PROVISIONAL

Source sequence(s)

AM233906

UniProtKB/Swiss-Prot

Q2A121

UniProtKB/TrEMBL

A0A0G2K675, B4F7E0

Related

ENSRNOP00000015718.4, ENSRNOT00000015718.8

Conserved Domains (2) summary

pfam12933
Location:36 → 322

FTO_NTD; FTO catalytic domain

pfam12934
Location:326 → 495

FTO_CTD; FTO C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

31456749..31865011 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097565.2 → XP_038953493.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X2

UniProtKB/TrEMBL

A0A0G2K675

Conserved Domains (2) summary

pfam12933
Location:36 → 322

FTO_NTD; FTO catalytic domain

pfam12934
Location:326 → 452

FTO_CTD; FTO C-terminal domain
XM_039097564.2 → XP_038953492.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X1

UniProtKB/TrEMBL

A0A0G2K675

Conserved Domains (2) summary

pfam12933
Location:36 → 322

FTO_NTD; FTO catalytic domain

pfam12934
Location:326 → 453

FTO_CTD; FTO C-terminal domain
XM_039097566.2 → XP_038953494.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X3

Conserved Domains (2) summary

pfam12933
Location:6 → 151

FTO_NTD; FTO catalytic domain

pfam12934
Location:155 → 323

FTO_CTD; FTO C-terminal domain
XM_063277861.1 → XP_063133931.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X3
XM_039097568.2 → XP_038953496.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X3

Conserved Domains (2) summary

pfam12933
Location:6 → 151

FTO_NTD; FTO catalytic domain

pfam12934
Location:155 → 323

FTO_CTD; FTO C-terminal domain
XM_039097567.2 → XP_038953495.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X3

Conserved Domains (2) summary

pfam12933
Location:6 → 151

FTO_NTD; FTO catalytic domain

pfam12934
Location:155 → 323

FTO_CTD; FTO C-terminal domain