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    Gcnt1 glucosaminyl (N-acetyl) transferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64043, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gcnt1provided by RGD
    Official Full Name
    glucosaminyl (N-acetyl) transferase 1provided by RGD
    Primary source
    RGD:621370
    See related
    EnsemblRapid:ENSRNOG00000062686 AllianceGenome:RGD:621370
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    core 2 GlcNAc-T
    Summary
    Enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity. Involved in response to insulin. Located in extracellular space. Orthologous to human GCNT1 (glucosaminyl (N-acetyl) transferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 145.4), Spleen (RPKM 83.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gcnt1 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (224145104..224182496, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (214718344..214755735, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (236547729..236585037)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene forkhead box B2 Neighboring gene prune homolog 2 with BCH domain Neighboring gene uncharacterized LOC134483972 Neighboring gene acyl-protein thioesterase 1-like Neighboring gene riboflavin kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. beta1,6 N-acetylglucosaminyltransferase (core 2 GlcNAc-T) expression in normal rat tissues and different cell lines: evidence for complex mechanisms of regulation. VanderElst IE, et al. Glycobiology, 1998 Jul. PMID 9621114
    2. Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue. Nishio Y, et al. J Clin Invest, 1995 Oct. PMID 7560067, Free PMC Article
    3. Golgi phosphoprotein 3 determines cell binding properties under dynamic flow by controlling Golgi localization of core 2 N-acetylglucosaminyltransferase 1. Ali MF, et al. J Biol Chem, 2012 Nov 16. PMID 23027862, Free PMC Article
    4. Glycosyltransferase function in core 2-type protein O glycosylation. Stone EL, et al. Mol Cell Biol, 2009 Jul. PMID 19349303, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion molecule production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in core 2 O-glycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycoprotein biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to insulin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi cisterna ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
    Names
    beta1,6 N-acetylglucosaminyltransferase
    enzymatic glycosylation-regulating
    glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
    glucosaminyl transferase 1, core 2
    NP_071612.1
    XP_006231209.1
    XP_006231212.1
    XP_038945223.1
    XP_038945229.1
    XP_063128739.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022276.2 → NP_071612.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

      See identical proteins and their annotated locations for NP_071612.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZR94, Q64165
      Conserved Domains (1) summary
      pfam02485
      Location:123 → 391
      Branch; Core-2/I-Branching enzyme

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      224145104..224182496 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089301.2 → XP_038945229.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZR94, Q64165
      Conserved Domains (1) summary
      pfam02485
      Location:123 → 391
      Branch; Core-2/I-Branching enzyme

    2. XM_006231147.4 → XP_006231209.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006231209.1

      UniProtKB/TrEMBL
      A0A8I5ZR94, Q64165
      Related
      ENSRNOP00000080877.1, ENSRNOT00000119573.2
      Conserved Domains (1) summary
      pfam02485
      Location:123 → 391
      Branch; Core-2/I-Branching enzyme

    3. XM_039089295.2 → XP_038945223.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZR94, Q64165
      Conserved Domains (1) summary
      pfam02485
      Location:123 → 391
      Branch; Core-2/I-Branching enzyme

    4. XM_063272669.1 → XP_063128739.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZR94, Q64165
      Related
      ENSRNOP00000095789.1, ENSRNOT00000118591.2

    5. XM_006231150.4 → XP_006231212.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006231212.1

      UniProtKB/TrEMBL
      A0A8I5ZR94, Q64165
      Related
      ENSRNOP00000083711.1, ENSRNOT00000108297.2
      Conserved Domains (1) summary
      pfam02485
      Location:123 → 391
      Branch; Core-2/I-Branching enzyme
    Nucleotide Protein Strain
    Heading Accession and Version

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