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    Fhit fragile histidine triad diadenosine triphosphatase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60398, updated on 9-Dec-2024

    Summary

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    Symbol
    Fhitprovided by RGD
    Full Name
    fragile histidine triad diadenosine triphosphataseprovided by RGD
    Primary source
    RGD:620448
    See related
    EnsemblRapid:ENSRNOG00000064939 AllianceGenome:RGD:620448
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables bis(5'-adenosyl)-triphosphatase activity and nickel cation binding activity. Involved in diadenosine triphosphate catabolic process. Predicted to be located in cytosol and fibrillar center. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in carcinoma (multiple); invasive ductal carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human FHIT (fragile histidine triad diadenosine triphosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 87.8), Brain (RPKM 51.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fhit in Genome Data Viewer
    Location:
    15p15
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (16365401..17872901)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (13935029..15442620)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (15697292..16862873)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096925 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 2 Neighboring gene WW domain binding protein 11, pseudogene 9 Neighboring gene uncharacterized LOC120097099 Neighboring gene ribosomal protein L12, pseudogene 11 Neighboring gene uncharacterized LOC120097098 Neighboring gene uncharacterized LOC120097100 Neighboring gene uncharacterized LOC103693285 Neighboring gene uncharacterized LOC134482085 Neighboring gene uncharacterized LOC120096926

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genetic linkage of prostate cancer risk to the chromosome 3 region bearing FHIT. Larson GP, et al. Cancer Res, 2005 Feb 1. PMID 15705877
    2. Clinicopathological significance of Fhit protein expression in stage I non-small cell lung carcinoma. Tomizawa Y, et al. Cancer Res, 1998 Dec 1. PMID 9850082
    3. Different immunohistochemical patterns of Fhit protein expression in renal neoplasms. Eyzaguirre EJ, et al. Mod Pathol, 1999 Oct. PMID 10530564
    4. Clinicopathological significance of fragile histidine triad transcription protein expression in endometrial carcinomas. Segawa T, et al. Clin Cancer Res, 2000 Jun. PMID 10873085
    5. Analysis of the fragile histidine triad (FHIT) gene in lobular breast cancer. Huiping C, et al. Eur J Cancer, 2000 Aug. PMID 10930803

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircFhit Modulates GABAergic Synaptic Transmission via Regulating the Parental Gene Fhit Expression in the Spinal Dorsal Horn in a Rat Model of Neuropathic Pain.
      Title: CircFhit Modulates GABAergic Synaptic Transmission via Regulating the Parental Gene Fhit Expression in the Spinal Dorsal Horn in a Rat Model of Neuropathic Pain.
    2. Nickel(II) treatment down-regulated Fhit expression.
      Title: Differential gene expression in nickel(II)-treated normal rat kidney cells.
    3. Distribution of Fhit protein in rat tissues and its intracellular localization.
      Title: Distribution of Fhit protein in rat tissues and its intracellular localization.
    4. These results suggest that Fhit alterations may play important roles in hepatocarcinogenesis due to choline deficiency in rats.
      Title: Fhit gene alterations in hepatocarcinogenesis induced by a choline-deficient L-amino acid-defined diet in rats.
    5. examination of alterations in N-nitrosodiethylamine-induced hepatocellular carcinoma
      Title: Alterations of the Fhit gene in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats.
    6. There is an overall association of Fhit expression with regulatory region methylation, and hypermethylation patterns did not vary with carcinogen.
      Title: Hypermethylation patterns in the Fhit regulatory region are tissue specific.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables adenosine 5'-monophosphoramidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenosine 5'-monophosphoramidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenosine 5'-monophosphoramidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables adenylylsulfatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylylsulfatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenylylsulfatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables adenylylsulfate-ammonia adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylylsulfate-ammonia adenylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenylylsulfate-ammonia adenylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables bis(5'-adenosyl)-triphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bis(5'-adenosyl)-triphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables bis(5'-adenosyl)-triphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bis(5'-adenosyl)-triphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nickel cation binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in diadenosine triphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in diadenosine triphosphate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in diadenosine triphosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in diadenosine triphosphate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in purine nucleotide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine nucleotide metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bis(5'-adenosyl)-triphosphatase
    Names
    AP3A hydrolase
    AP3Aase
    adenosine 5'-monophosphoramidase FHIT
    adenylylsulfatase
    adenylylsulfate-ammonia adenylyltransferase
    diadenosine 5',5'''-P1,P3-triphosphate hydrolase
    dinucleosidetriphosphatase
    fragile histidine triad protein
    XP_038949559.1
    XP_038949560.1
    XP_063130670.1
    XP_063130671.1
    XP_063130672.1
    XP_063130673.1
    XP_063130674.1
    XP_063130675.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431357.1 → NP_001418286.1  bis(5'-adenosyl)-triphosphatase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q9JIX3
      UniProtKB/TrEMBL
      A0A8I5ZQ19, A6K0A2

    2. NM_001431358.1 → NP_001418287.1  bis(5'-adenosyl)-triphosphatase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q9JIX3
      UniProtKB/TrEMBL
      A0A8I5ZQ19, A6K0A2

    3. NM_001431359.1 → NP_001418288.1  bis(5'-adenosyl)-triphosphatase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q9JIX3
      UniProtKB/TrEMBL
      A0A8I5ZQ19, A6K0A2

    4. NM_001431360.1 → NP_001418289.1  bis(5'-adenosyl)-triphosphatase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q9JIX3
      UniProtKB/TrEMBL
      A0A8I5ZQ19, A6K0A2

    5. NM_001431361.1 → NP_001418290.1  bis(5'-adenosyl)-triphosphatase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q9JIX3
      UniProtKB/TrEMBL
      A0A8I5ZQ19, A6K0A2

    6. NM_001431362.1 → NP_001418291.1  bis(5'-adenosyl)-triphosphatase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q9JIX3
      UniProtKB/TrEMBL
      A0A8I5ZQ19, A6K0A2

    7. NM_001431363.1 → NP_001418292.1  bis(5'-adenosyl)-triphosphatase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q9JIX3
      UniProtKB/TrEMBL
      A0A8I5ZQ19, A6K0A2

    8. NM_001431364.1 → NP_001418293.1  bis(5'-adenosyl)-triphosphatase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    9. NM_001431365.1 → NP_001418294.1  bis(5'-adenosyl)-triphosphatase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    10. NM_021774.2 → NP_068542.2  bis(5'-adenosyl)-triphosphatase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q9JIX3
      UniProtKB/TrEMBL
      A0A8I5ZQ19, A6K0A2
      Related
      ENSRNOP00000080145.1, ENSRNOT00000109492.2

    RNA

    1. NR_197206.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    2. NR_197207.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    3. NR_197208.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      16365401..17872901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274603.1 → XP_063130673.1  bis(5'-adenosyl)-triphosphatase isoform X2

    2. XM_063274602.1 → XP_063130672.1  bis(5'-adenosyl)-triphosphatase isoform X2

    3. XM_039093632.2 → XP_038949560.1  bis(5'-adenosyl)-triphosphatase isoform X2

      Conserved Domains (1) summary
      cd01275
      Location:5 → 124
      FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...

    4. XM_063274601.1 → XP_063130671.1  bis(5'-adenosyl)-triphosphatase isoform X2

    5. XM_063274604.1 → XP_063130674.1  bis(5'-adenosyl)-triphosphatase isoform X3

      UniProtKB/Swiss-Prot
      Q9JIX3

    6. XM_039093631.2 → XP_038949559.1  bis(5'-adenosyl)-triphosphatase isoform X1

      UniProtKB/Swiss-Prot
      Q9JIX3
      Conserved Domains (1) summary
      cd01275
      Location:18 → 137
      FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...

    7. XM_063274600.1 → XP_063130670.1  bis(5'-adenosyl)-triphosphatase isoform X2

    8. XM_063274605.1 → XP_063130675.1  bis(5'-adenosyl)-triphosphatase isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIX3.1 GenPept UniProtKB/Swiss-Prot:Q9JIX3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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