C4bpa complement component 4 binding protein, alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C4bpaprovided by RGD
Official Full Name: complement component 4 binding protein, alphaprovided by RGD
Primary source: RGD:2235
See related: EnsemblRapid:ENSRNOG00000004062 AllianceGenome:RGD:2235
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: C4BP
Summary: Predicted to enable complement binding activity. Predicted to be involved in several processes, including negative regulation of complement activation, classical pathway; regulation of opsonization; and response to symbiotic bacterium. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be located in acrosomal matrix; cell body; and outer acrosomal membrane. Predicted to be part of zona pellucida receptor complex. Predicted to be active in extracellular space and plasma membrane. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human C4BPA (complement component 4 binding protein alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 3725.1) See more
Orthologs: human all
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Genomic context

Location:: 13q13

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (44627959..44663552, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (42075715..42111205, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (47342090..47377580, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decline in the expression of C4 binding protein alpha-chain gene during ageing of the rat liver
Title: Decline in the expression of C4 binding protein alpha-chain gene during ageing of the rat liver.

Submit: New GeneRIF Correction

General gene information

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Markers

RH94833 (e-PCR)
- UniSTS:120079

RH94834 (e-PCR)
- UniSTS:120080

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables complement binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell mediated immunity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of complement activation, classical pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of complement activation, classical pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of opsonization	IEA Inferred from Electronic Annotation more info
involved_in regulation of opsonization	ISO Inferred from Sequence Orthology more info
involved_in response to symbiotic bacterium	IEA Inferred from Electronic Annotation more info
involved_in response to symbiotic bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within single fertilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal matrix	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in outer acrosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of zona pellucida receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C4b-binding protein alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012516.2 → NP_036648.2 C4b-binding protein alpha chain

See identical proteins and their annotated locations for NP_036648.2

Status: PROVISIONAL

Source sequence(s)

BC088165

UniProtKB/TrEMBL

A6IBY8, Q5M891

Related

ENSRNOP00000005461.3, ENSRNOT00000005461.7

Conserved Domains (4) summary

cd00033
Location:182 → 243

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00032
Location:372 → 429

CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

PHA02927
Location:300 → 544

PHA02927; secreted complement-binding protein; Provisional

pfam00084
Location:490 → 544

Sushi; Sushi repeat (SCR repeat)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

44627959..44663552 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090318.2 → XP_038946246.1 C4b-binding protein alpha chain isoform X1

Conserved Domains (2) summary

PHA02927
Location:123 → 367

PHA02927; secreted complement-binding protein; Provisional

pfam18453
Location:370 → 418

C4bp_oligo; Oligomerization domain of C4b-binding protein alpha
XM_063272018.1 → XP_063128088.1 C4b-binding protein alpha chain isoform X2