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    Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29741, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pik3r2provided by RGD
    Official Full Name
    phosphoinositide-3-kinase regulatory subunit 2provided by RGD
    Primary source
    RGD:68341
    See related
    EnsemblRapid:ENSRNOG00000019228 AllianceGenome:RGD:68341
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including 1-phosphatidylinositol-3-kinase regulator activity; enzyme binding activity; and phosphatidylinositol 3-kinase regulatory subunit binding activity. Involved in negative regulation of cell migration involved in sprouting angiogenesis. Predicted to be located in focal adhesion and nucleus. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in pancreatic ductal adenocarcinoma. Orthologous to human PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 115.8), Brain (RPKM 115.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pik3r2 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18699389..18708045)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18665517..18674067)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20415109..20424982)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene interleukin 12 receptor subunit beta 1 Neighboring gene microtubule associated serine/threonine kinase 3 Neighboring gene uncharacterized LOC134482470 Neighboring gene IFI30, lysosomal thiol reductase Neighboring gene MPV17 mitochondrial inner membrane protein like 2 Neighboring gene RAB3A, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC108697

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity  
    enables kinase activity  
    enables phosphatidylinositol 3-kinase regulatory subunit binding  
    enables phosphatidylinositol 3-kinase regulatory subunit binding  
    enables phosphotyrosine residue binding  
    enables phosphotyrosine residue binding  
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein phosphatase binding  
    enables protein phosphatase binding  
    enables receptor tyrosine kinase binding  
    enables receptor tyrosine kinase binding  
    Items 1 - 25 of 35
    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to insulin stimulus  
    involved_in insulin receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in intracellular glucose homeostasis  
    involved_in intracellular glucose homeostasis  
    involved_in intracellular glucose homeostasis  
    involved_in negative regulation of MAPK cascade  
    involved_in negative regulation of MAPK cascade  
    involved_in negative regulation of cell migration involved in sprouting angiogenesis PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of cell adhesion  
    acts_upstream_of_or_within positive regulation of cell adhesion  
    involved_in positive regulation of protein import into nucleus  
    involved_in positive regulation of protein import into nucleus  
    involved_in positive regulation of protein import into nucleus  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in protein transport  
    involved_in regulation of actin filament polymerization  
    acts_upstream_of_or_within regulation of actin filament polymerization  
    involved_in regulation of autophagy  
    involved_in regulation of autophagy  
    involved_in regulation of autophagy  
    involved_in regulation of protein localization to plasma membrane  
    acts_upstream_of_or_within regulation of protein localization to plasma membrane  
    involved_in regulation of stress fiber assembly  
    acts_upstream_of_or_within regulation of stress fiber assembly  
    involved_in response to endoplasmic reticulum stress  
    involved_in response to endoplasmic reticulum stress  
    involved_in response to endoplasmic reticulum stress  
    Items 1 - 25 of 35
    Component Evidence Code Pubs
    located_in cytosol  
    located_in focal adhesion  
    located_in focal adhesion  
    located_in nucleus  
    located_in nucleus  
    located_in nucleus  
    part_of phosphatidylinositol 3-kinase complex, class IA  
    part_of phosphatidylinositol 3-kinase complex, class IA  
    part_of phosphatidylinositol 3-kinase complex, class IA  

    General protein information

    Preferred Names
    phosphatidylinositol 3-kinase regulatory subunit beta
    Names
    PI3-kinase p85 subunit beta
    PI3-kinase regulatory subunit beta
    PI3-kinase subunit p85-beta
    PI3K regulatory subunit beta
    phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta
    phosphatidylinositol 3-kinase, regulartory subunit, polypeptide 2
    phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
    phosphoinositide-3-kinase, regulatory subunit 2 (beta)
    ptdIns-3-kinase p85-beta
    ptdIns-3-kinase regulatory subunit beta
    ptdIns-3-kinase regulatory subunit p85-beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022185.2NP_071521.2  phosphatidylinositol 3-kinase regulatory subunit beta

      See identical proteins and their annotated locations for NP_071521.2

      Status: PROVISIONAL

      Source sequence(s)
      BC089805
      UniProtKB/Swiss-Prot
      Q63788
      UniProtKB/TrEMBL
      A6KA00, F7F9A3, Q5FVS6
      Related
      ENSRNOP00000026210.3, ENSRNOT00000026210.7
      Conserved Domains (6) summary
      cd09930
      Location:609711
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:318426
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd11909
      Location:780
      SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
      cd12926
      Location:431591
      iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
      pfam16454
      Location:430589
      PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
      cl02570
      Location:110302
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      18699389..18708045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094436.2XP_038950364.1  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1

      UniProtKB/Swiss-Prot
      Q63788
      Conserved Domains (5) summary
      cd09930
      Location:628730
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:337445
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd11909
      Location:780
      SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
      cd12926
      Location:450610
      iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
      cl02570
      Location:110321
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    2. XM_063275283.1XP_063131353.1  phosphatidylinositol 3-kinase regulatory subunit beta isoform X2

      UniProtKB/Swiss-Prot
      Q63788
      UniProtKB/TrEMBL
      A6KA00, F7F9A3, Q5FVS6
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