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    Rpa1 replication protein A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287524, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rpa1provided by RGD
    Official Full Name
    replication protein A1provided by RGD
    Primary source
    RGD:1307376
    See related
    EnsemblRapid:ENSRNOG00000003123 AllianceGenome:RGD:1307376
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cb1-727
    Summary
    Enables single-stranded DNA binding activity. Predicted to be involved in DNA metabolic process; meiotic cell cycle; and protein localization to site of double-strand break. Predicted to act upstream of or within several processes, including homeostasis of number of cells within a tissue; in utero embryonic development; and positive regulation of cell population proliferation. Part of DNA replication factor A complex. Orthologous to human RPA1 (replication protein A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 385.9), Heart (RPKM 209.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rpa1 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (60647185..60698279, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (60148869..60199970, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (62140419..62191518, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene reticulon 4 receptor-like 1 Neighboring gene uncharacterized LOC120095264 Neighboring gene ATP synthase subunit g, mitochondrial-like Neighboring gene F-box protein 5, pseudogene 1 Neighboring gene ribosomal protein L37, pseudogene 4 Neighboring gene SET and MYND domain containing 4 Neighboring gene serpin family F member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Replication protein A is the major single-stranded DNA binding protein detected in mammalian cell extracts by gel retardation assays and UV cross-linking of long and short single-stranded DNA molecules. Seroussi E, et al. J Biol Chem, 1993 Apr 5. PMID 8463251
    2. Human replication protein A unfolds telomeric G-quadruplexes. Salas TR, et al. Nucleic Acids Res, 2006. PMID 16973897, Free PMC Article
    3. Cellular functions of human RPA1. Multiple roles of domains in replication, repair, and checkpoints. Haring SJ, et al. J Biol Chem, 2008 Jul 4. PMID 18469000, Free PMC Article
    4. Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice. Wang Y, et al. Nat Genet, 2005 Jul. PMID 15965476
    5. Binding polarity of RPA to telomeric sequences and influence of G-quadruplex stability. Safa L, et al. Biochimie, 2014 Aug. PMID 24747047

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-rich strand telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin-protein adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within meiotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mismatch repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA replication factor A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DNA replication factor A complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of DNA replication factor A complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in condensed chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lateral element ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    replication protein A 70 kDa DNA-binding subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394069.1 → NP_001380998.1  replication protein A 70 kDa DNA-binding subunit

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2KAT3
      Related
      ENSRNOP00000078632.1, ENSRNOT00000116502.2
      Conserved Domains (1) summary
      TIGR00617
      Location:2 → 612
      rpa1; replication factor-a protein 1 (rpa1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      60647185..60698279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767961.4 → XP_008766183.1  replication protein A 70 kDa DNA-binding subunit isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAT3
      Conserved Domains (3) summary
      cd04474
      Location:82 → 184
      RPA1_DBD_A; RPA1_DBD_A: A subfamily of OB folds corresponding to the second OB fold, the ssDNA-binding domain (DBD)-A, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...
      pfam08646
      Location:357 → 502
      Rep_fac-A_C; Replication factor-A C terminal domain
      pfam16900
      Location:201 → 285
      REPA_OB_2; Replication protein A OB domain

    2. XM_063268676.1 → XP_063124746.1  replication protein A 70 kDa DNA-binding subunit isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001047843.1: Suppressed sequence

      Description
      NM_001047843.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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