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    Kpna1 karyopherin subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288064, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kpna1provided by RGD
    Official Full Name
    karyopherin subunit alpha 1provided by RGD
    Primary source
    RGD:735064
    See related
    EnsemblRapid:ENSRNOG00000051711 AllianceGenome:RGD:735064
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables nuclear localization sequence binding activity. Involved in NLS-bearing protein import into nucleus. Located in dendrite and nucleus. Orthologous to human KPNA1 (karyopherin subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 430.4), Heart (RPKM 285.1) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kpna1 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (78221165..78279778, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (64715844..64774647, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (67652573..67717180, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene mitochondrial matrix import factor 23 Neighboring gene family with sequence similarity 162, member A Neighboring gene WD repeat domain 5B Neighboring gene uncharacterized LOC134481077 Neighboring gene poly (ADP-ribose) polymerase family, member 9 Neighboring gene deltex E3 ubiquitin ligase 3L Neighboring gene caspase 6, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity  
    enables nuclear import signal receptor activity  
    enables nuclear import signal receptor activity  
    enables nuclear localization sequence binding  
    enables nuclear localization sequence binding PubMed 
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus  
    involved_in NLS-bearing protein import into nucleus  
    involved_in NLS-bearing protein import into nucleus PubMed 
    acts_upstream_of_or_within NLS-bearing protein import into nucleus  
    involved_in NLS-bearing protein import into nucleus  
    involved_in postsynapse to nucleus signaling pathway  
    involved_in postsynapse to nucleus signaling pathway  
    involved_in postsynapse to nucleus signaling pathway  
    involved_in protein import into nucleus  
    involved_in regulation of apoptotic process  
    acts_upstream_of_or_within regulation of apoptotic process  
    involved_in regulation of canonical Wnt signaling pathway  
    acts_upstream_of_or_within regulation of canonical Wnt signaling pathway  
    involved_in satellite cell activation involved in skeletal muscle regeneration  
    acts_upstream_of_or_within satellite cell activation involved in skeletal muscle regeneration  
    involved_in skeletal muscle satellite cell proliferation  
    acts_upstream_of_or_within skeletal muscle satellite cell proliferation  
    acts_upstream_of_or_within skeletal muscle tissue regeneration  
    Component Evidence Code Pubs
    part_of NLS-dependent protein nuclear import complex  
    part_of NLS-dependent protein nuclear import complex  
    located_in cytoplasm  
    located_in cytosol  
    is_active_in cytosol  
    located_in cytosol  
    located_in dendrite PubMed 
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    is_active_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in postsynaptic density  
    is_active_in postsynaptic density  

    General protein information

    Preferred Names
    importin subunit alpha-5
    Names
    importin alpha-5
    importin subunit alpha-1
    karyopherin alpha 1
    karyopherin/importin alpha-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198726.2 → NP_942021.2  importin subunit alpha-5

      See identical proteins and their annotated locations for NP_942021.2

      Status: PROVISIONAL

      Source sequence(s)
      AY779025
      UniProtKB/Swiss-Prot
      P83953
      UniProtKB/TrEMBL
      A0A0G2JXY5, Q56R20
      Conserved Domains (2) summary
      COG5064
      Location:33 → 516
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:128 → 154
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      78221165..78279778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088121.2 → XP_038944049.1  importin subunit alpha-5 isoform X1

      UniProtKB/Swiss-Prot
      P83953
      UniProtKB/TrEMBL
      A0A0G2JXY5, Q56R20
      Related
      ENSRNOP00000071569.2, ENSRNOT00000078285.3
      Conserved Domains (2) summary
      COG5064
      Location:33 → 516
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:128 → 154
      ARM; armadillo repeat [structural motif]
    2. XM_017597922.3 → XP_017453411.1  importin subunit alpha-5 isoform X1

      UniProtKB/Swiss-Prot
      P83953
      UniProtKB/TrEMBL
      A0A0G2JXY5, Q56R20
      Conserved Domains (2) summary
      COG5064
      Location:33 → 516
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:128 → 154
      ARM; armadillo repeat [structural motif]
    3. XM_039088122.2 → XP_038944050.1  importin subunit alpha-5 isoform X2

      Conserved Domains (2) summary
      COG5064
      Location:1 → 315
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:172 → 208
      ARM; armadillo repeat [structural motif]
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