U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Cops7a COP9 signalosome subunit 7A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312710, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cops7aprovided by RGD
    Official Full Name
    COP9 signalosome subunit 7Aprovided by RGD
    Primary source
    RGD:1310070
    See related
    EnsemblRapid:ENSRNOG00000016778 AllianceGenome:RGD:1310070
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in protein deneddylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of COP9 signalosome. Orthologous to human COPS7A (COP9 signalosome subunit 7A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 280.0), Heart (RPKM 188.1) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cops7a in Genome Data Viewer
    Location:
    4q42
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159452878..159478878, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157766626..157792632, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157479549..157486944, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene parathymosin Neighboring gene myeloid leukemia factor 2 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120102387 Neighboring gene PILR alpha associated neural protein Neighboring gene zinc finger protein 384 Neighboring gene uncharacterized LOC102554095

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in COP9 signalosome assembly  
    involved_in protein deneddylation  
    Component Evidence Code Pubs
    part_of COP9 signalosome  
    part_of COP9 signalosome  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    COP9 signalosome complex subunit 7a
    Names
    COP9 (constitutive photomorphogenic) homolog, subunit 7a
    COP9 complex subunit 7a
    COP9 constitutive photomorphogenic homolog subunit 7A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047098.2NP_001040563.2  COP9 signalosome complex subunit 7a isoform 2

      See identical proteins and their annotated locations for NP_001040563.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, and uses a distinct terminal exon and 3' UTR, compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB259153, BI296165, FM059742
      UniProtKB/TrEMBL
      A0A8I5ZU93, G3V8Z9
      Related
      ENSRNOP00000081985.2, ENSRNOT00000101137.2
      Conserved Domains (2) summary
      smart00088
      Location:87177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:166215
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
    2. NM_001164091.1NP_001157563.1  COP9 signalosome complex subunit 7a isoform 1

      See identical proteins and their annotated locations for NP_001157563.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
      Source sequence(s)
      AB259153, AI603423, CB326021, DV719333, FM037577, FM122308
      UniProtKB/TrEMBL
      A0A8I6GK17, A6ILN5
      Conserved Domains (2) summary
      smart00088
      Location:87177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:166215
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      159452878..159478878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237368.5XP_006237430.1  COP9 signalosome complex subunit 7a isoform X3

      See identical proteins and their annotated locations for XP_006237430.1

      UniProtKB/TrEMBL
      A0A8I5ZU93, G3V8Z9
      Conserved Domains (2) summary
      smart00088
      Location:87177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:166215
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
    2. XM_039107676.2XP_038963604.1  COP9 signalosome complex subunit 7a isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZU93, G3V8Z9
      Conserved Domains (2) summary
      smart00088
      Location:87177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:166215
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
    3. XM_063286139.1XP_063142209.1  COP9 signalosome complex subunit 7a isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZU93, G3V8Z9
    4. XM_039107674.2XP_038963602.1  COP9 signalosome complex subunit 7a isoform X1

      UniProtKB/TrEMBL
      F1MAA2, G3V8Z9
      Conserved Domains (2) summary
      smart00088
      Location:106196
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:185234
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
    5. XM_039107678.2XP_038963606.1  COP9 signalosome complex subunit 7a isoform X4

      UniProtKB/TrEMBL
      A0A8I6GK17, A6ILN5
      Conserved Domains (2) summary
      smart00088
      Location:87177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:166215
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
    6. XM_063286140.1XP_063142210.1  COP9 signalosome complex subunit 7a isoform X4

      UniProtKB/TrEMBL
      A0A8I6GK17, A6ILN5
    7. XM_039107675.2XP_038963603.1  COP9 signalosome complex subunit 7a isoform X2

      UniProtKB/TrEMBL
      A0A8I6GK17
      Related
      ENSRNOP00000031800.4, ENSRNOT00000038281.6
      Conserved Domains (2) summary
      smart00088
      Location:106196
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:185234
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
    External link. Please review our privacy policy.