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    Nmt1 N-myristoyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 259274, updated on 9-Dec-2024

    Summary

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    Symbol
    Nmt1provided by RGD
    Full Name
    N-myristoyltransferase 1provided by RGD
    Primary source
    RGD:628642
    See related
    EnsemblRapid:ENSRNOG00000002989 AllianceGenome:RGD:628642
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables myristoyltransferase activity. Predicted to be involved in N-terminal peptidyl-glycine N-myristoylation; cellular ketone metabolic process; and protein localization to membrane. Predicted to act upstream of or within N-terminal protein myristoylation and in utero embryonic development. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol. Orthologous to human NMT1 (N-myristoyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 312.3), Thymus (RPKM 249.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nmt1 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (88488918..88525496)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87988826..88025405)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (91126689..91160721)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L22 like 4 Neighboring gene complement C1q like 1 Neighboring gene dephospho-CoA kinase domain containing Neighboring gene phospholipase C, delta 3 Neighboring gene acyl-CoA binding domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Altered expression and localization of N-myristoyltransferase in experimentally induced rat model of ischemia-reperfusion. Rajala RV, et al. J Cell Biochem, 2002. PMID 12210757
    2. Expression and activities of N-myristoyltransferase and calcineurin in normal and inflamed lungs. Charavaryamath C, et al. Exp Lung Res, 2009 Nov. PMID 19916857
    3. N-myristoyltransferase: a potential novel diagnostic marker for colon cancer. Shrivastav A, et al. J Transl Med, 2007 Nov 16. PMID 18021392, Free PMC Article
    4. Identification and characterization of recombinant and native rat myristoyl-CoA: protein N-myristoyltransferases. Rioux V, et al. Mol Cell Biochem, 2006 Jun. PMID 16538398
    5. Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fraction. Glover CJ, et al. J Biol Chem, 1997 Nov 7. PMID 9353336

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cell-specific increase expression of myristoyltransferase and calcineurin in lung epithelium and endothelium
      Title: Expression and activities of N-myristoyltransferase and calcineurin in normal and inflamed lungs.
    2. N-myristoyltransferase may have a role in progression of colonic neoplasms
      Title: N-myristoyltransferase: a potential novel diagnostic marker for colon cancer.
    3. NMT1 protein exhibited functional myristoyltransferase activity.
      Title: Identification and characterization of recombinant and native rat myristoyl-CoA: protein N-myristoyltransferases.
    4. Altered expression and localization of N-myristoyltransferase in experimentally induced rat model of ischemia-reperfusion.
      Title: Altered expression and localization of N-myristoyltransferase in experimentally induced rat model of ischemia-reperfusion.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glycylpeptide N-tetradecanoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycylpeptide N-tetradecanoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycylpeptide N-tetradecanoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycylpeptide N-tetradecanoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables myristoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myristoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidyl-lysine N6-myristoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-lysine N6-myristoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidyl-lysine N6-myristoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-glycine N-myristoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-terminal peptidyl-glycine N-myristoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within N-terminal protein myristoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ketone metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ketone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glycylpeptide N-tetradecanoyltransferase 1
    Names
    NMT 1
    myristoyl-CoA:protein N-myristoyltransferase 1
    peptide N-myristoyltransferase 1
    type I N-myristoyltransferase
    NP_683689.1
    XP_038941229.1
    XP_038941230.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_148891.2 → NP_683689.1  glycylpeptide N-tetradecanoyltransferase 1

      See identical proteins and their annotated locations for NP_683689.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097277
      UniProtKB/Swiss-Prot
      Q8K1Q0
      UniProtKB/TrEMBL
      A0A8I6ATE4, A6HJP2
      Related
      ENSRNOP00000004046.5, ENSRNOT00000004046.8
      Conserved Domains (3) summary
      COG5092
      Location:86 → 484
      NMT1; N-myristoyl transferase [Lipid metabolism]
      pfam01233
      Location:137 → 291
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:308 → 483
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      88488918..88525496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085301.2 → XP_038941229.1  glycylpeptide N-tetradecanoyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ATE4
      Conserved Domains (1) summary
      COG5092
      Location:16 → 414
      NMT1; N-myristoyl transferase [Lipid metabolism]

    2. XM_039085302.2 → XP_038941230.1  glycylpeptide N-tetradecanoyltransferase 1 isoform X2

      Conserved Domains (2) summary
      pfam01233
      Location:1 → 105
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:122 → 308
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1Q0.1 GenPept UniProtKB/Swiss-Prot:Q8K1Q0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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