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    Cpap centrosome assembly and centriole elongation protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305909, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Cpapprovided by RGD
    Official Full Name
    centrosome assembly and centriole elongation proteinprovided by RGD
    Primary source
    RGD:1310464
    See related
    EnsemblRapid:ENSRNOG00000022597 AllianceGenome:RGD:1310464
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cenpj
    Summary
    Predicted to enable several functions, including gamma-tubulin binding activity; identical protein binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including cilium assembly; microtubule cytoskeleton organization; and positive regulation of cell cycle process. Predicted to act upstream of or within several processes, including astral microtubule nucleation; organelle assembly; and positive regulation of non-motile cilium assembly. Predicted to be located in ciliary basal body and cytoplasm. Predicted to be part of procentriole replication complex. Predicted to be active in centriole and centrosome. Human ortholog(s) of this gene implicated in Seckel syndrome 4; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 6. Orthologous to human CENPJ (centromere protein J). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 60.8), Adrenal (RPKM 49.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cpap in Genome Data Viewer
    Location:
    15p12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (34742838..34806020, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (30627206..30690384, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (36745672..36809228, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ATPase H+/K+ transporting non-gastric alpha2 subunit Neighboring gene ring finger protein 17 Neighboring gene TM2 domain-containing protein 1 pseudogene Neighboring gene poly (ADP-ribose) polymerase family, member 4 Neighboring gene small nucleolar RNA SNORA5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel microtubule-destabilizing motif in CPAP that binds to tubulin heterodimers and inhibits microtubule assembly. Hung LY, et al. Mol Biol Cell, 2004 Jun. PMID 15047868, Free PMC Article
    2. CPAP is required for cilia formation in neuronal cells. Wu KS, et al. Biol Open, 2012 Jun 15. PMID 23213448, Free PMC Article
    3. A novel deletion mutation in CENPJ gene in a Pakistani family with autosomal recessive primary microcephaly. Gul A, et al. J Hum Genet, 2006. PMID 16900296
    4. Novel CENPJ mutation causes Seckel syndrome. Al-Dosari MS, et al. J Med Genet, 2010 Jun. PMID 20522431
    5. Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated with the gamma-tubulin complex. Hung LY, et al. Mol Cell Biol, 2000 Oct. PMID 11003675, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables gamma-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within astral microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within centriole assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centriole elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of centriole elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of procentriole replication complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centromere protein J

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395117.1 → NP_001382046.1  centromere protein J

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6KH99, D4A194
      Related
      ENSRNOP00000110817.1, ENSRNOT00000165696.1
      Conserved Domains (2) summary
      COG1196
      Location:901 → 1046
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07202
      Location:1264 → 1297
      Tcp10_C; T-complex protein 10 C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      34742838..34806020 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093312.2 → XP_038949240.1  centromere protein J isoform X1

      UniProtKB/TrEMBL
      A6KH99, D4A194
      Conserved Domains (2) summary
      COG1196
      Location:901 → 1046
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07202
      Location:1264 → 1297
      Tcp10_C; T-complex protein 10 C-terminus

    2. XM_039093309.2 → XP_038949237.1  centromere protein J isoform X1

      UniProtKB/TrEMBL
      A6KH99, D4A194
      Conserved Domains (2) summary
      COG1196
      Location:901 → 1046
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07202
      Location:1264 → 1297
      Tcp10_C; T-complex protein 10 C-terminus

    3. XM_039093311.2 → XP_038949239.1  centromere protein J isoform X1

      UniProtKB/TrEMBL
      A6KH99, D4A194
      Conserved Domains (2) summary
      COG1196
      Location:901 → 1046
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07202
      Location:1264 → 1297
      Tcp10_C; T-complex protein 10 C-terminus

    4. XM_039093307.2 → XP_038949235.1  centromere protein J isoform X1

      UniProtKB/TrEMBL
      A6KH99, D4A194
      Conserved Domains (2) summary
      COG1196
      Location:901 → 1046
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07202
      Location:1264 → 1297
      Tcp10_C; T-complex protein 10 C-terminus

    5. XM_039093313.2 → XP_038949241.1  centromere protein J isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZNZ1, A6KH99, D4A194
      Related
      ENSRNOP00000080142.1, ENSRNOT00000096584.2
      Conserved Domains (2) summary
      COG1196
      Location:901 → 1046
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07202
      Location:1226 → 1259
      Tcp10_C; T-complex protein 10 C-terminus

    6. XM_063274261.1 → XP_063130331.1  centromere protein J isoform X2

      UniProtKB/TrEMBL
      A6KH99, D4A194
      Related
      ENSRNOP00000106573.1, ENSRNOT00000132147.1

    7. XM_039093315.2 → XP_038949243.1  centromere protein J isoform X4

    RNA

    1. XR_010057815.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107265.2: Suppressed sequence

      Description
      NM_001107265.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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