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    Nsd3 nuclear receptor binding SET domain protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290831, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nsd3provided by RGD
    Official Full Name
    nuclear receptor binding SET domain protein 3provided by RGD
    Primary source
    RGD:1308980
    See related
    EnsemblRapid:ENSRNOG00000015621 AllianceGenome:RGD:1308980
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Whsc1l1
    Summary
    Predicted to enable protein-lysine N-methyltransferase activity and transcription regulator activator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to act upstream of or within chromatin remodeling and negative regulation of DNA-templated transcription. Predicted to be located in chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in myeloid leukemia. Orthologous to human NSD3 (nuclear receptor binding SET domain protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 122.1), Adrenal (RPKM 100.7) and 9 other tissues See more
    Orthologs
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    Try the new Transcript table

    Genomic context

    See Nsd3 in Genome Data Viewer
    Location:
    16q12.4
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (73056748..73170082, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (66354030..66466202, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (71126276..71237118, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene DDHD domain containing 2 Neighboring gene uncharacterized LOC134482516 Neighboring gene phospholipid phosphatase 5 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 2 Neighboring gene small nucleolar RNA SNORA15 Neighboring gene Fibroblast growth factor receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in chromatin  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase NSD3
    Names
    Wolf-Hirschhorn syndrome candidate 1-like 1
    NP_001099560.1
    XP_006253369.1
    XP_006253371.1
    XP_006253373.1
    XP_008769572.1
    XP_038950324.1
    XP_038950327.1
    XP_038950328.1
    XP_038950329.1
    XP_038950330.1
    XP_063131314.1
    XP_063131315.1
    XP_063131316.1
    XP_063131317.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106090.1NP_001099560.1  histone-lysine N-methyltransferase NSD3

      See identical proteins and their annotated locations for NP_001099560.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473970
      UniProtKB/TrEMBL
      A0A8I5ZLN5, A6IW11, D3ZK47
      Related
      ENSRNOP00000060879.1, ENSRNOT00000066974.4
      Conserved Domains (9) summary
      cd05837
      Location:268384
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:9101011
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:10541104
      AWS; associated with SET domains
      smart00317
      Location:11051228
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd15649
      Location:704746
      PHD1_NSD3; PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15652
      Location:752798
      PHD2_NSD3; PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15658
      Location:865904
      PHD4_NSD3; PHD finger 4 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15661
      Location:12821324
      PHD5_NSD3; PHD finger 5 found in nuclear SET domain-containing protein 3 (NSD3)
      cl22851
      Location:799851
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      73056748..73170082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094399.2XP_038950327.1  histone-lysine N-methyltransferase NSD3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZLN5
      Conserved Domains (10) summary
      cd05837
      Location:274390
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:9661059
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      cd15649
      Location:711753
      PHD1_NSD3; PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15652
      Location:759805
      PHD2_NSD3; PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15658
      Location:925960
      PHD4_NSD3; PHD finger 4 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15661
      Location:13301372
      PHD5_NSD3; PHD finger 5 found in nuclear SET domain-containing protein 3 (NSD3)
      cd19212
      Location:11521293
      SET_NSD3; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins
      pfam17907
      Location:11121150
      AWS; AWS domain
      pfam17982
      Location:13711420
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:806858
      PHD_SF; PHD finger superfamily
    2. XM_063275246.1XP_063131316.1  histone-lysine N-methyltransferase NSD3 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZLN5
    3. XM_006253311.5XP_006253373.1  histone-lysine N-methyltransferase NSD3 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZLN5
      Conserved Domains (9) summary
      cd05837
      Location:274390
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:9161009
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:10521102
      AWS; associated with SET domains
      smart00317
      Location:11031226
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd15649
      Location:710752
      PHD1_NSD3; PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15652
      Location:758804
      PHD2_NSD3; PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15658
      Location:871910
      PHD4_NSD3; PHD finger 4 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15661
      Location:12801322
      PHD5_NSD3; PHD finger 5 found in nuclear SET domain-containing protein 3 (NSD3)
      cl22851
      Location:805857
      PHD_SF; PHD finger superfamily
    4. XM_006253309.5XP_006253371.1  histone-lysine N-methyltransferase NSD3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZLN5
      Conserved Domains (9) summary
      cd05837
      Location:274390
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:9651058
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:11011151
      AWS; associated with SET domains
      smart00317
      Location:11521264
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd15649
      Location:710752
      PHD1_NSD3; PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15652
      Location:758804
      PHD2_NSD3; PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15658
      Location:924959
      PHD4_NSD3; PHD finger 4 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15661
      Location:13181360
      PHD5_NSD3; PHD finger 5 found in nuclear SET domain-containing protein 3 (NSD3)
      cl22851
      Location:805857
      PHD_SF; PHD finger superfamily
    5. XM_006253307.5XP_006253369.1  histone-lysine N-methyltransferase NSD3 isoform X4

      See identical proteins and their annotated locations for XP_006253369.1

      UniProtKB/TrEMBL
      A0A0G2K001, A0A8I5ZLN5
      Conserved Domains (9) summary
      cd05837
      Location:274390
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:9651058
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      smart00570
      Location:11011151
      AWS; associated with SET domains
      smart00317
      Location:11521275
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd15649
      Location:710752
      PHD1_NSD3; PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15652
      Location:758804
      PHD2_NSD3; PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15658
      Location:924959
      PHD4_NSD3; PHD finger 4 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15661
      Location:13291371
      PHD5_NSD3; PHD finger 5 found in nuclear SET domain-containing protein 3 (NSD3)
      cl22851
      Location:805857
      PHD_SF; PHD finger superfamily
    6. XM_063275245.1XP_063131315.1  histone-lysine N-methyltransferase NSD3 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZLN5
    7. XM_039094402.2XP_038950330.1  histone-lysine N-methyltransferase NSD3 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZLN5
      Conserved Domains (10) summary
      cd05837
      Location:274390
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:9171010
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      cd15649
      Location:711753
      PHD1_NSD3; PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15652
      Location:759805
      PHD2_NSD3; PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15658
      Location:872911
      PHD4_NSD3; PHD finger 4 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15661
      Location:12811323
      PHD5_NSD3; PHD finger 5 found in nuclear SET domain-containing protein 3 (NSD3)
      cd19212
      Location:11031244
      SET_NSD3; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins
      pfam17907
      Location:10631101
      AWS; AWS domain
      pfam17982
      Location:13221371
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:806858
      PHD_SF; PHD finger superfamily
    8. XM_039094401.2XP_038950329.1  histone-lysine N-methyltransferase NSD3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZLN5
      Conserved Domains (10) summary
      cd05837
      Location:274390
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:9661059
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      cd15649
      Location:711753
      PHD1_NSD3; PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15652
      Location:759805
      PHD2_NSD3; PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15658
      Location:925960
      PHD4_NSD3; PHD finger 4 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15661
      Location:13191361
      PHD5_NSD3; PHD finger 5 found in nuclear SET domain-containing protein 3 (NSD3)
      cl40432
      Location:11521282
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
      pfam17907
      Location:11121150
      AWS; AWS domain
      pfam17982
      Location:13601409
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:806858
      PHD_SF; PHD finger superfamily
    9. XM_039094396.2XP_038950324.1  histone-lysine N-methyltransferase NSD3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZLN5
      Related
      ENSRNOP00000071250.2, ENSRNOT00000088458.3
    10. XM_063275244.1XP_063131314.1  histone-lysine N-methyltransferase NSD3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZLN5
    11. XM_039094400.2XP_038950328.1  histone-lysine N-methyltransferase NSD3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZLN5
      Conserved Domains (10) summary
      cd05837
      Location:274390
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:9661059
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      cd15649
      Location:711753
      PHD1_NSD3; PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15652
      Location:759805
      PHD2_NSD3; PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15658
      Location:925960
      PHD4_NSD3; PHD finger 4 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15661
      Location:13301372
      PHD5_NSD3; PHD finger 5 found in nuclear SET domain-containing protein 3 (NSD3)
      cd19212
      Location:11521293
      SET_NSD3; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins
      pfam17907
      Location:11121150
      AWS; AWS domain
      pfam17982
      Location:13711420
      C5HCH; NSD Cys-His rich domain
      cl22851
      Location:806858
      PHD_SF; PHD finger superfamily
    12. XM_063275247.1XP_063131317.1  histone-lysine N-methyltransferase NSD3 isoform X9

    13. XM_008771350.3XP_008769572.1  histone-lysine N-methyltransferase NSD3 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZK70
      Related
      ENSRNOP00000076954.1, ENSRNOT00000119483.2
      Conserved Domains (1) summary
      cd05837
      Location:274390
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
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