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    Wfdc6a WAP four-disulfide core domain 6A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685153, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wfdc6aprovided by RGD
    Official Full Name
    WAP four-disulfide core domain 6Aprovided by RGD
    Primary source
    RGD:1597730
    See related
    EnsemblRapid:ENSRNOG00000042526 AllianceGenome:RGD:1597730
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of flagellated sperm motility. Predicted to be active in extracellular space. Orthologous to human WFDC6 (WAP four-disulfide core domain 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 113.3), Lung (RPKM 15.5) and 2 other tissues See more
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    Genomic context

    See Wfdc6a in Genome Data Viewer
    Location:
    3q42
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (173724681..173728489, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (153305336..153309144, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (161036703..161040511, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene bolA family member 2, pseudogene 4 Neighboring gene WAP four-disulfide core domain 2 Neighboring gene serine peptidase inhibitor, Kunitz type, 3 Neighboring gene epididymal peptidase inhibitor Neighboring gene WAP four-disulfide core domain 8 Neighboring gene WAP four-disulfide core domain 6B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in extracellular space  

    General protein information

    Preferred Names
    WAP four-disulfide core domain protein 6A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001246283.2NP_001233212.2  WAP four-disulfide core domain protein 6A precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JX99
      Related
      ENSRNOP00000086668.2, ENSRNOT00000097649.2
      Conserved Domains (2) summary
      pfam00014
      Location:86138
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam00095
      Location:4281
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      173724681..173728489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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