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    Nol10 nucleolar protein 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313981, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nol10provided by RGD
    Official Full Name
    nucleolar protein 10provided by RGD
    Primary source
    RGD:1359447
    See related
    EnsemblRapid:ENSRNOG00000005344 AllianceGenome:RGD:1359447
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Orthologous to human NOL10 (nucleolar protein 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 78.6), Spleen (RPKM 67.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nol10 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (45861773..45954067)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (40144217..40225353)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (42656661..42745099)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel modifier subfamily F member 1 Neighboring gene protein disulfide isomerase family A, member 6 Neighboring gene ATPase H+ transporting V1 subunit C2 Neighboring gene craniofacial development protein 1 like 1 Neighboring gene proteasome activator subunit 3, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire. Staub E, et al. Bioessays, 2004 May. PMID 15112237
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014076.1 → NP_001014098.1  nucleolar protein 10

      See identical proteins and their annotated locations for NP_001014098.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081954
      UniProtKB/Swiss-Prot
      Q66H99
      UniProtKB/TrEMBL
      A6HAU7
      Related
      ENSRNOP00000007169.5, ENSRNOT00000007169.8
      Conserved Domains (4) summary
      COG4942
      Location:558 → 672
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      sd00039
      Location:55 → 95
      7WD40; WD40 repeat [structural motif]
      pfam08159
      Location:482 → 508
      NUC153; NUC153 domain
      cl29593
      Location:182 → 339
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      45861773..45954067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261889.1 → XP_063117959.1  nucleolar protein 10 isoform X1

      UniProtKB/Swiss-Prot
      Q66H99
      UniProtKB/TrEMBL
      A6HAU7

    2. XM_063261890.1 → XP_063117960.1  nucleolar protein 10 isoform X2

    RNA

    1. XR_005505511.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66H99.1 GenPept UniProtKB/Swiss-Prot:Q66H99

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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