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    Kazn kazrin, periplakin interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313672, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kaznprovided by RGD
    Official Full Name
    kazrin, periplakin interacting proteinprovided by RGD
    Primary source
    RGD:1359147
    See related
    EnsemblRapid:ENSRNOG00000014322 AllianceGenome:RGD:1359147
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kaz
    Summary
    Predicted to be involved in keratinization. Predicted to be located in several cellular components, including cornified envelope; desmosome; and nuclear speck. Orthologous to human KAZN (kazrin, periplakin interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 46.4), Kidney (RPKM 34.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kazn in Genome Data Viewer
    Location:
    5q36
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (159675803..160666084, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (154392793..155381567, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (160637235..161730513, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene forkhead associated phosphopeptide binding domain 1 Neighboring gene transmembrane protein 51 Neighboring gene uncharacterized LOC134487032 Neighboring gene uncharacterized LOC134487033 Neighboring gene uncharacterized LOC134487030 Neighboring gene uncharacterized LOC134479045 Neighboring gene uncharacterized LOC134479046 Neighboring gene uncharacterized LOC102556543 Neighboring gene uncharacterized LOC120103134 Neighboring gene large ribosomal subunit protein uL5-like Neighboring gene uncharacterized LOC103692503 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene PR/SET domain 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane. Groot KR, et al. J Cell Biol, 2004 Aug 30. PMID 15337775, Free PMC Article
    2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105638

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in keratinization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cornified envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cornified envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in desmosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in desmosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kazrin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014070.4 → NP_001014092.2  kazrin isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6AAP0, A6ITY6
      Conserved Domains (1) summary
      pfam13863
      Location:129 → 242
      DUF4200; Domain of unknown function (DUF4200)

    2. NM_001415945.1 → NP_001402874.1  kazrin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q5FWS6
      UniProtKB/TrEMBL
      A0A0H2UHL8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      159675803..160666084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593423.3 → XP_017448912.1  kazrin isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHL8
      Related
      ENSRNOP00000019447.8, ENSRNOT00000019447.8

    2. XM_006239310.5 → XP_006239372.2  kazrin isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHL8
      Conserved Domains (4) summary
      cd09564
      Location:465 → 534
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:544 → 608
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:630 → 701
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      COG1196
      Location:32 → 262
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_006239311.5 → XP_006239373.1  kazrin isoform X3

      UniProtKB/TrEMBL
      A0A0H2UHL8
      Related
      ENSRNOP00000088366.2, ENSRNOT00000118606.2
      Conserved Domains (6) summary
      cd09564
      Location:437 → 506
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:516 → 580
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:602 → 673
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      smart00454
      Location:437 → 504
      SAM; Sterile alpha motif
      pfam05010
      Location:71 → 246
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam13863
      Location:118 → 231
      DUF4200; Domain of unknown function (DUF4200)

    4. XM_039110084.2 → XP_038966012.1  kazrin isoform X4

      UniProtKB/TrEMBL
      A0A0H2UHL8
      Conserved Domains (4) summary
      cd09564
      Location:349 → 418
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:428 → 492
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:514 → 585
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      COG1196
      Location:25 → 158
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FWS6.2 GenPept UniProtKB/Swiss-Prot:Q5FWS6

    Gene LinkOut

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