U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363113, updated on 9-Dec-2024

    Summary

    Symbol
    Syncripprovided by RGD
    Full Name
    synaptotagmin binding, cytoplasmic RNA interacting proteinprovided by RGD
    Primary source
    RGD:1305683
    See related
    EnsemblRapid:ENSRNOG00000000204 AllianceGenome:RGD:1305683
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ab2-339; hnRNP Q
    Summary
    Enables mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Involved in circadian rhythm; negative regulation of mRNA modification; and positive regulation of translation. Located in neuronal cell body and proximal dendrite. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human SYNCRIP (synaptotagmin binding cytoplasmic RNA interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 303.0), Spleen (RPKM 256.9) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Syncrip in Genome Data Viewer
    Location:
    8q31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (98282358..98315412, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (89402487..89435517, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (96100692..96266342, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene sorting nexin 14 Neighboring gene 5' nucleotidase, ecto Neighboring gene myosin light polypeptide 6-like Neighboring gene small nucleolar RNA SNORD50 Neighboring gene synaptotagmin binding, cytoplasmic RNA interacting protein, pseudogene 2 Neighboring gene zinc finger protein 949 Neighboring gene tripartite motif-containing 43A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding  
    enables mRNA 3'-UTR binding PubMed 
    enables mRNA 5'-UTR binding  
    enables mRNA 5'-UTR binding PubMed 
    enables poly(A) binding  
    Process Evidence Code Pubs
    involved_in CRD-mediated mRNA stabilization  
    involved_in CRD-mediated mRNA stabilization  
    involved_in CRD-mediated mRNA stabilization  
    involved_in RNA splicing  
    involved_in cellular response to type II interferon  
    involved_in cellular response to type II interferon  
    involved_in circadian rhythm PubMed 
    involved_in mRNA modification  
    involved_in mRNA processing  
    involved_in negative regulation of mRNA modification PubMed 
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  
    involved_in negative regulation of translation  
    involved_in negative regulation of translation  
    involved_in positive regulation of cytoplasmic translation  
    involved_in positive regulation of cytoplasmic translation  
    involved_in positive regulation of translation PubMed 
    Items 1 - 20 of 27
    Component Evidence Code Pubs
    part_of CRD-mediated mRNA stability complex  
    part_of CRD-mediated mRNA stability complex  
    part_of CRD-mediated mRNA stability complex  
    part_of CRD-mediated mRNA stability complex  
    part_of GAIT complex  
    part_of GAIT complex  
    part_of catalytic step 2 spliceosome  
    part_of catalytic step 2 spliceosome  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in endoplasmic reticulum  
    is_active_in glutamatergic synapse PubMed 
    part_of histone pre-mRNA 3'end processing complex  
    part_of histone pre-mRNA 3'end processing complex  
    part_of mCRD-mediated mRNA stability complex  
    part_of mCRD-mediated mRNA stability complex  
    located_in membrane  
    located_in neuronal cell body PubMed 
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    is_active_in postsynaptic density PubMed 
    located_in proximal dendrite PubMed 
    part_of ribonucleoprotein complex  
    part_of ribonucleoprotein complex  
    part_of ribonucleoprotein complex  
    Items 1 - 20 of 27

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein Q
    Names
    hnRNP-Q
    liver regeneration-related protein LRRG077

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047916.3NP_001041381.1  heterogeneous nuclear ribonucleoprotein Q isoform 1

      See identical proteins and their annotated locations for NP_001041381.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q7TP47
      UniProtKB/TrEMBL
      A0A8I5ZZ72
      Related
      ENSRNOP00000048433.4, ENSRNOT00000041655.6
      Conserved Domains (4) summary
      cd12483
      Location:71149
      RRM1_hnRNPQ; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein Q (hnRNP Q)
      cd12489
      Location:151235
      RRM2_hnRNPQ; RNA recognition motif 2 in vertebrate heterogeneous nuclear ribonucleoprotein Q (hnRNP Q)
      cd12494
      Location:247318
      RRM3_hnRNPR; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein R (hnRNP R)
      TIGR01648
      Location:50525
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    2. NM_001395649.1NP_001382578.1  heterogeneous nuclear ribonucleoprotein Q isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K9J1, A0A8I5ZZ72
      Related
      ENSRNOP00000075015.2, ENSRNOT00000078891.3
      Conserved Domains (2) summary
      TIGR01648
      Location:103557
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21066
      Location:23107
      NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins
    3. NM_001395650.1NP_001382579.1  heterogeneous nuclear ribonucleoprotein Q isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZZ72
      Conserved Domains (2) summary
      TIGR01648
      Location:103553
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21066
      Location:23107
      NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins
    4. NM_001395651.1NP_001382580.1  heterogeneous nuclear ribonucleoprotein Q isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      M0R735
      Related
      ENSRNOP00000065252.3, ENSRNOT00000074515.4
      Conserved Domains (2) summary
      TIGR01648
      Location:103615
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21066
      Location:23107
      NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      98282358..98315412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265796.1XP_063121866.1  heterogeneous nuclear ribonucleoprotein Q isoform X2

      UniProtKB/TrEMBL
      M0R735
    2. XM_063265795.1XP_063121865.1  heterogeneous nuclear ribonucleoprotein Q isoform X1

      UniProtKB/TrEMBL
      M0R735
    3. XM_063265799.1XP_063121869.1  heterogeneous nuclear ribonucleoprotein Q isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZZ72
    4. XM_006243514.4XP_006243576.1  heterogeneous nuclear ribonucleoprotein Q isoform X3

      UniProtKB/TrEMBL
      M0R735
      Conserved Domains (3) summary
      cd12495
      Location:291362
      RRM3_hnRNPQ; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein Q (hnRNP Q)
      TIGR01648
      Location:103569
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cl17169
      Location:161222
      RRM_SF; RNA recognition motif (RRM) superfamily
    5. XM_006243518.5XP_006243580.1  heterogeneous nuclear ribonucleoprotein Q isoform X4

      Conserved Domains (4) summary
      cd12483
      Location:63141
      RRM1_hnRNPQ; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein Q (hnRNP Q)
      cd12489
      Location:143227
      RRM2_hnRNPQ; RNA recognition motif 2 in vertebrate heterogeneous nuclear ribonucleoprotein Q (hnRNP Q)
      cd12494
      Location:239310
      RRM3_hnRNPR; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein R (hnRNP R)
      TIGR01648
      Location:5517
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    6. XM_063265798.1XP_063121868.1  heterogeneous nuclear ribonucleoprotein Q isoform X5

    7. XM_039081769.2XP_038937697.1  heterogeneous nuclear ribonucleoprotein Q isoform X7

      Conserved Domains (1) summary
      TIGR01648
      Location:1309
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    External link. Please review our privacy policy.