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    Zpr1 ZPR1 zinc finger [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500989, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zpr1provided by RGD
    Official Full Name
    ZPR1 zinc fingerprovided by RGD
    Primary source
    RGD:1562173
    See related
    EnsemblRapid:ENSRNOG00000018481 AllianceGenome:RGD:1562173
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfp259; RGD1562173
    Summary
    Predicted to enable receptor tyrosine kinase binding activity; translation initiation factor binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including Cajal body organization; blastocyst growth; and nervous system development. Predicted to act upstream of or within with a positive effect on DNA replication. Predicted to be located in growth cone; nuclear lumen; and perikaryon. Predicted to be active in Cajal body; axon; and cytoplasm. Orthologous to human ZPR1 (ZPR1 zinc finger). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 134.5), Testes (RPKM 120.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Zpr1 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (55461839..55471413)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (46564898..46574719)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (50563047..50572621)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein A4 Neighboring gene apolipoprotein A5 Neighboring gene uncharacterized LOC134480162 Neighboring gene BUD13 homolog Neighboring gene RIKEN cDNA 4931429L15 gene like Neighboring gene uncharacterized LOC134480043

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables receptor tyrosine kinase binding  
    enables translation initiation factor binding  
    enables translation initiation factor binding  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in Cajal body organization  
    involved_in Cajal body organization  
    involved_in DNA endoreduplication  
    acts_upstream_of_or_within_positive_effect DNA replication  
    involved_in apoptotic process involved in development  
    involved_in axon development  
    involved_in axon development  
    involved_in cellular response to epidermal growth factor stimulus  
    involved_in inner cell mass cell proliferation  
    involved_in microtubule cytoskeleton organization  
    involved_in negative regulation of motor neuron apoptotic process  
    involved_in positive regulation of RNA splicing  
    involved_in positive regulation of cell cycle  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of growth  
    involved_in positive regulation of protein import into nucleus  
    involved_in positive regulation of protein import into nucleus  
    involved_in pre-mRNA catabolic process  
    involved_in regulation of myelination  
    involved_in spinal cord development  
    involved_in trophectodermal cell proliferation  
    Component Evidence Code Pubs
    is_active_in Cajal body  
    located_in Cajal body  
    located_in Gemini of coiled bodies  
    is_active_in axon  
    located_in axon  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in growth cone  
    located_in neuronal cell body  
    located_in nucleolus  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in perikaryon  

    General protein information

    Preferred Names
    zinc finger protein ZPR1
    Names
    zinc finger protein 259

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001137646.1NP_001131118.1  zinc finger protein ZPR1

      See identical proteins and their annotated locations for NP_001131118.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473975
      UniProtKB/TrEMBL
      A0A8I6AUQ7, A6J476, D3ZWN1
      Related
      ENSRNOP00000025149.4, ENSRNOT00000025149.7
      Conserved Domains (2) summary
      smart00709
      Location:257416
      Zpr1; Duplicated domain in the epidermal growth factor- and elongation factor-1alpha-binding protein Zpr1. Also present in archaeal proteins
      pfam03367
      Location:49206
      zf-ZPR1; ZPR1 zinc-finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      55461839..55471413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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